17597-24-9

Basic information

• Product Name: (4beta,5beta)-4,5-epoxypregnane-3,20-dione
• CAS NO: 17597-24-9
• Molecular Formula: C₂₁H₃₀O₃
• Molecular Weight: 330.4611
• Mol File: 17597-24-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 458.4°C at 760 mmHg
• Flash Point: 200°C
• Density: 1.16g/cm³
• Vapor Pressure: 1.38E-08mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: (4beta,5beta)-4,5-epoxypregnane-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (4beta,5beta)-4,5-epoxypregnane-3,20-dione(17597-24-9)
• EPA Substance Registry System: (4beta,5beta)-4,5-epoxypregnane-3,20-dione(17597-24-9)

Safety Data

• Hazardous Substances Data: 17597-24-9(Hazardous Substances Data)

Usage

General Description

(4beta,5beta)-4,5-epoxypregnane-3,20-dione is a steroid compound with a molecular formula of C21H28O3. It is also known as epoxypregnane and is a derivative of progesterone. (4beta,5beta)-4,5-epoxypregnane-3,20-dione is a key intermediate in the synthesis of corticosteroids and has important biological and pharmacological activities. It has been studied for its potential as an anti-inflammatory and immunosuppressive agent. Additionally, (4beta,5beta)-4,5-epoxypregnane-3,20-dione may have potential applications in the treatment of various inflammatory and autoimmune diseases. Its unique chemical structure and pharmacological properties make it a molecule of interest for further research and development in the field of medicine.

Upstream product

• 57-83-0 Progesterone 

Downstream Products

• 1164-81-4 4-Chloro-pregn-4-ene-3,20-dione 
• 57-83-0 progesterone 
• 650-66-8 4-Hydroxy-pregnen-(4)-dion-(3,20) 

Relevant articles and documents

RUTHENIUM COMPLEX AND PRODUCTION METHOD THEREOF, CATALYST, AND PRODUCTION METHOD OF OXYGEN-CONTAINING COMPOUND

PROBLEM TO BE SOLVED: To provide a ruthenium complex that is particularly useful as a catalyst for oxidizing a substrate having a carbon-hydrogen bond. SOLUTION: The ruthenium complex represented by the general formula (i) or a cis conformer thereof is provided. In the general formula (i), R1 represents H, a phenyl group or a substituted phenyl group; R2 represents H, a phenyl group or an alkyl group; L1 represents halogen or water molecule; L2 represents triphenylphosphine, pyridine, imidazole or dimethylsulfoxide; X represents halogen; and n represents 1 or 2. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPO&INPIT

Synthesis and cytotoxic activity of some novel steroidal C-17 pyrazolinyl derivatives

Fourteen novel steroidal C-17 pyrazolinyl derivatives 9a-g and 10a-g were synthesized from commercially available progesterone and tested for their cytotoxic activity against brine shrimp (Artemia salina) and three human cancer cell lines (NCI-H460, HeLa, and HepG2). Some of these synthetic compounds exhibited significant cytotoxic activity, and treatment of HeLa cells with compound 10b resulted in the cell population arrest in the S phase. A structure-activity relationship was discussed.

Highly efficient epoxidation of unsaturated steroids using magnesium bis(monoperoxyphthalate) hexahydrate

Fast generation of epoxides from the corresponding homoallylic and allylic steroidal olefins was developed by using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP) as oxidant suspended in acetonitrile (CH3CN) at reflux temperature. The protocol involves the use of a safe readily available oxidant along with an easy work-up, which renders the process very efficient. Selective 4,5- and 5,6-epoxidations of steroids are reported. Among them, highly stereoselective epoxidation of Δ5-B-nor-cholestanes was achieved. Moreover, the method is chemoselective for the 5,6-position and can be applied to the epoxidation of ring-A enones.