1165-22-6 Usage
Description
1-[2-(2-Thienyl)ethyl]-4-(N-propionylanilino)piperidine is an anilide compound that is formed through the formal condensation of the aryl amino group of N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid. It features a unique structure that includes a thienylethyl group and a propionylanilino moiety, which may contribute to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
1-[2-(2-Thienyl)ethyl]-4-(N-propionylanilino)piperidine is used as a pharmaceutical compound for its potential therapeutic properties. The specific application reason is not provided in the materials, but the unique structural features of this compound suggest that it may have valuable biological activities, making it a candidate for further research and development in the pharmaceutical sector.
Used in Chemical Research:
1-[2-(2-Thienyl)ethyl]-4-(N-propionylanilino)piperidine is used as a research chemical for studying its properties and potential applications. The synthesis and characterization of this compound can provide insights into the behavior of similar anilide structures and contribute to the understanding of their reactivity and interactions with other molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 1165-22-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,6 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1165-22:
(6*1)+(5*1)+(4*6)+(3*5)+(2*2)+(1*2)=56
56 % 10 = 6
So 1165-22-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H26N2OS/c1-2-20(23)22(17-7-4-3-5-8-17)18-10-13-21(14-11-18)15-12-19-9-6-16-24-19/h3-9,16,18H,2,10-15H2,1H3
1165-22-6Relevant articles and documents
Improved method for the total synthesis of thiofentanyl
Hosseini, S. J.,Moosavi, S. M.,Parsa, H.,Taghizadeh, M. J.
, (2020)
Thiofentanyl is a potent analgesic and anesthetic drug that belongs to the microreceptor agonist group and is mainly used in animal's anesthesia. We present an optimized synthesis route for synthesis of thiofentanyl using nanocatalysts such as MCM-41-SO3H and SBA-15-Ph-PrSO3H as green, heterogeneous and recyclable catalysts according to the strategy. The intermediate 2-(thiophen-2-yl) ethyl methanesulfonate (1) easily obtained after conversion of the alcohol functional group into the mesylate leaving group using methanesulfonyl chloride (97% yield). The alkylation of commercially available 4-piperidone monohydrate hydrochloride with 2-(thiophen-2-yl) ethyl methanesulfonate in the presence of phase transfer catalyst was then carried out giving N-[2-(2-thienyl) ethyl]-4-piperidone (2) with 90% yield. N-[2-(2-thienyl)ethyl]-4-piperidone was then reacted with aniline in the presence of MCM-41-SO3H catalyst giving the imine derivative which reduced with sodium triacetoxyborohydride to N-phenyl-1-(2-(thiophen-2-yl)ethyl) piperidine-4-amine (ANTP) (4) with 80% yield. ANTP was finally acylated using propionyl chloride to achieve thiofentanyl (5) with 90% yield. High yields, mild reaction conditions, decreased reaction times, and convenient workup were the advantages of this method compared to the previous work.