5402-55-1 Usage
Description
2-Thiopheneethanol is a thiophene derivative characterized by the presence of a thiophene ring and an ethanol functional group. It is an organic compound with potential applications in various industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
2-Thiopheneethanol is used as a key intermediate in the synthesis of biologically active compounds. It serves as a precursor for the preparation of oligothiophene isothiocyanates, which are utilized as fluorescent markers for biopolymers. These markers are essential in the study and analysis of biopolymers, contributing to advancements in the field of biochemistry and molecular biology.
2-Thiopheneethanol is also used as an intermediate in the production of the analgesic Sulfentanyl. As an analgesic, Sulfentanyl is employed to alleviate pain and is particularly useful in managing severe or chronic pain conditions.
Furthermore, 2-Thiopheneethanol is utilized in the synthesis of Clopidogrel Hydrogen Sulfate (C587250), an antithrombotic agent. Antithrombotic drugs, like Clopidogrel Hydrogen Sulfate, are crucial in the prevention and treatment of blood clots, which can lead to life-threatening conditions such as heart attacks and strokes.
Used in Chemical Industry:
In the chemical industry, 2-Thiopheneethanol is used as an intermediate for the preparation of antithrombotics thiophene chlorine match piperidine. These compounds are essential in the development of medications that help prevent blood clot formation, which is a significant concern in various medical conditions.
Additionally, 2-Thiopheneethanol is employed as a ticlopidine intermediate. Ticlopidine is an antiplatelet agent used to reduce the risk of stroke and heart attack in patients with certain medical conditions. Its role as an intermediate in the synthesis of ticlopidine highlights the importance of 2-Thiopheneethanol in the development of life-saving medications.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 477, 1942 DOI: 10.1021/ja01255a001The Journal of Organic Chemistry, 59, p. 4323, 1994 DOI: 10.1021/jo00094a056
Check Digit Verification of cas no
The CAS Registry Mumber 5402-55-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,0 and 2 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5402-55:
(6*5)+(5*4)+(4*0)+(3*2)+(2*5)+(1*5)=71
71 % 10 = 1
So 5402-55-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H8OS/c7-4-3-6-2-1-5-8-6/h1-2,5,7H,3-4H2
5402-55-1Relevant articles and documents
Catalytic removal of tert-butyldimethylsilyl (TBS) ether by PVP-I
Ke, Yanxiong,Lu, Guangying,Ren, Jiangmeng,Wang, Di,Zeng, Bu-Bing
, (2019/09/06)
A mild, efficient and rapid protocol the deprotection of alcoholic TBDMS ethers using PVP-1 as catalyst in methanol, the procedure of deprotection of various TBDMS ethers were found to be very convenient, easy work-up, high yielding.
1,2,5-oxadiazole derivative used as indoleamine 2,3-dioxygenase inhibitor
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Paragraph 0113-0116, (2019/10/01)
The invention belongs to the technical field of 1,2,5-oxadiazole derivatives, and particularly relates to a 1,2,5-oxadiazole derivative or a pharmaceutically acceptable salt thereof which is used as an indoleamine 2,3-dioxygenase inhibitor. The structure of the 1,2,5-oxadiazole derivative or the pharmaceutically acceptable salt thereof used as the IDO inhibitor is shown in the following formula I.The invention provides a general formula compound I with a novel structure. Experimental results show that some compounds have excellent IDO inhibitory activity and permeation performance at the sametime. The compound is expected to be marketed as a tumor molecular immunotherapeutic drug for cancer treatment.
Selective ligand-free cobalt-catalysed reduction of esters to aldehydes or alcohols
Rysak, Vincent,Descamps-Mandine, Armel,Simon, Pardis,Blanchard, Florent,Burylo, Laurence,Trentesaux, Martine,Vandewalle, Maxence,Collière, Vincent,Agbossou-Niedercorn, Francine,Michon, Christophe
, p. 3504 - 3512 (2018/07/29)
Cobalt(ii) salts combined with NaBHEt3 and eventually a base catalyse efficiently and selectively the reduction of esters to aldehydes or alcohols through hydrosilylation by using phenylsilane. Catalyst characterisation by XRD, XPS, TEM and STEM analyses indicates the materials were partially crystalline with the presence of cobalt nanoparticles. Control experiments suggested low valent Co(0) was the active catalytic species involved.