30433-91-1 Usage
Description
Thiophene-2-ethylamine, also known as 2-(thiophen-2-yl)ethanamine, is an aromatic amine that exists as a colorless to yellow liquid. It is known for its ability to undergo microwave-induced condensation with iminodiacetic acid, leading to the formation of corresponding piperazine-2,6-dione derivatives. Thiophene-2-ethylamine has been investigated as a potential substitute for the pyridine ligand, which can enhance the performance of poly(3-hexylthiophene)/CdSe hybrid solar cells.
Uses
Used in Pharmaceutical Industry:
Thiophene-2-ethylamine is used as a reactant in the synthesis of geldanamycin derivatives, which serve as HCV replication inhibitors targeting Hsp90. This application is significant in the development of treatments for Hepatitis C virus.
Used in Nanotechnology:
Thiophene-2-ethylamine is suitable for functionalizing multiwall carbon nanotubes (MWCNT). This application is crucial in the advancement of nanotechnology, as it allows for the enhancement of the properties and performance of carbon nanotubes in various applications.
Used in Chemical Synthesis:
Thiophene-2-ethylamine is used as a reactant in the synthesis of pyrimidine derivatives by reacting with various isothiocyanatoketones. Additionally, it is used in the synthesis of acylguanidine derivatives by reacting with aroyl S-methylisothiourea. These applications are essential in the development of new chemical compounds and materials with potential uses in various industries.
Synthesis
N,N-Dimethylformamide (DMF) reacts with thiophene to obtain 2-thiophenecarbaldehyde, then reacts with isopropyl chloroacetate to obtain 2-thiopheneacetaldehyde, and then reacts with hydroxylamine hydrochloride to obtain 2-thiopheneacetaldehyde oxime, and finally reduced to give 2-thiopheneethylamine.
Check Digit Verification of cas no
The CAS Registry Mumber 30433-91-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,4,3 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 30433-91:
(7*3)+(6*0)+(5*4)+(4*3)+(3*3)+(2*9)+(1*1)=81
81 % 10 = 1
So 30433-91-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H9NS/c7-4-3-6-2-1-5-8-6/h1-2,5H,3-4,7H2/p+1
30433-91-1Relevant articles and documents
Application of the cyanurate-isocyanurate rearrangement to amine synthesis: Preparation of 2-(2-thienyl)ethylamine
Harrington,Sanchez
, p. 1307 - 1314 (1993)
This communication describes a new method for preparation of 2-(2-thienyl)ethylamine, an important pharmaceutical intermediate. The method is based on the O-to-N migration of an alkyl group via cyanurate-isocyanurate rearrangment.
1,2,5-oxadiazole derivative used as indoleamine 2,3-dioxygenase inhibitor
-
, (2019/10/01)
The invention belongs to the technical field of 1,2,5-oxadiazole derivatives, and particularly relates to a 1,2,5-oxadiazole derivative or a pharmaceutically acceptable salt thereof which is used as an indoleamine 2,3-dioxygenase inhibitor. The structure of the 1,2,5-oxadiazole derivative or the pharmaceutically acceptable salt thereof used as the IDO inhibitor is shown in the following formula I.The invention provides a general formula compound I with a novel structure. Experimental results show that some compounds have excellent IDO inhibitory activity and permeation performance at the sametime. The compound is expected to be marketed as a tumor molecular immunotherapeutic drug for cancer treatment.
Hydrogenation of Nitriles and Ketones Catalyzed by an Air-Stable Bisphosphine Mn(I) Complex
Weber, Stefan,St?ger, Berthold,Kirchner, Karl
supporting information, p. 7212 - 7215 (2018/11/25)
Efficient hydrogenations of nitriles and ketones with molecular hydrogen catalyzed by a well-defined bench-stable bisphosphine Mn(I) complex are described. These reactions are environmentally benign and atomically economic, implementing an inexpensive, earth-abundant nonprecious metal catalyst. A range of aromatic and aliphatic nitriles and ketones were efficiently converted into primary amines and alcohols, respectively, in good to excellent yields. The hydrogenation of nitriles proceeds at 100 °C with catalyst loading of 2 mol % and 20 mol % base (t-BuOK), while the hydrogenation of ketones takes place already at 50 °C, with a catalyst loading of 1 mol % and 5 mol % of base. In both cases, a hydrogen pressure of 50 bar was applied.