60555-55-7

Basic information

• Product Name: 2-[2-(2-thienyl)ethyl]-1H-Isoindole-1,3(2H)-dione
• Synonyms: 2-[2-(2-thienyl)ethyl]-1H-Isoindole-1,3(2H)-dione
• CAS NO: 60555-55-7
• Molecular Formula: C₁₄H₁₁NO₂S
• Molecular Weight: 257.30764
• Mol File: 60555-55-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[2-(2-thienyl)ethyl]-1H-Isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2-thienyl)ethyl]-1H-Isoindole-1,3(2H)-dione(60555-55-7)
• EPA Substance Registry System: 2-[2-(2-thienyl)ethyl]-1H-Isoindole-1,3(2H)-dione(60555-55-7)

Safety Data

• Hazardous Substances Data: 60555-55-7(Hazardous Substances Data)

Usage

Chemical compound

2-[2-(2-thienyl)ethyl]-1H-Isoindole-1,3(2H)-dione

Class

Isoindole-1,3(2H)-diones

Moiety

Thienyl

Potential applications

Medicinal chemistry, drug discovery

Properties

Unique structure, potential biological activities

Uses

Building block for synthesis of pharmaceutical compounds

Further investigation

Required for specific uses and properties through research and testing.

Upstream product

• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 85-44-9 phthalic anhydride 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 136918-14-4 phthalimide 
• 201230-82-2 carbon monoxide 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 1126518-66-8 (E)-2-(2-(2-thienyl)vinyl)isoindoline-1,3-dione 

Downstream Products

• 188471-64-9 3-Hydroxy-3-phenyl-2-(2-thiophen-2-yl-ethyl)-2,3-dihydro-isoindol-1-one 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 

Relevant articles and documents

Regioselective Heck reaction of N-vinylphthalimide: A general strategy for the synthesis of (E)-N-styrylphthalimides and phenethylamines

The arylation of N-vinylphthalimide takes place at the β-position with aryl iodides, bromides and chlorides using palladium acetate [Pd(OAc) 2] or phenone oxime-derived palladacycles as catalysts under phosphine-free conditions. The reaction is succesfully carried out in organic solvents, such as DMF, in the presence of an organic base, such as dicyclohexylmethylamine, and with TBAB as additive at 120°C under conventional or microwave heating. (E)-N-Styrylphthalimides are mainly obtained using a rather low palladium loading (0.05-1 mol%). Similar catalytic efficiency is observed using a Kaiser oxime resin-derived palladacycle, which allows reuse of the polymeric complex for three cycles. The high regioselectivity observed supports that these palladacycles work as a source of Pd(0)spec ies operating mainly through a neutral mechanism. The syntheses of 2-thienylphenethylamine and mescaline have been performed by subsequent hydrogenation with Wilkinson's catalyst and hydrazinolysis.

Acyliminium ion cyclizations: Synthesis of thieno[2',3':3,4]pyrrolo[2,1-a]isoindolone and benzo[a]thieno[2,3(3,2 or 3,4)-g]indolizinones

N-acyliminium cyclizations onto thiophene to give thieno[2',3':3,4]pyrrolo[2,1-a]isoindolone (2b) and benzo[a]thieno[2,3(3,2 or 3,4)-g]indolizinones (12a-c) were studied.

Process for the preparation of 2-(2-thienyl)-ethylamine and derivatives thereof

This invention relates to a process for the preparation of compounds of the formula: STR1 in which R1 and R2 may represent hydrogen or a lower alkyl or optionally substituted phenyl radical, comprising aminating a derivative of the formula: STR2 in which R3 is an optionnally substituted alkyl, aryl or aralkyl group, and R1 and R2 are as defined for formula (I).