116774-46-0

Basic information

• Product Name: 2-Pyrrolidinecarboxamide, N-(phenylmethyl)-, (2S)-
• CAS NO: 116774-46-0
• Molecular Formula: C12H16N2O
• Molecular Weight: 204.272
• Mol File: 116774-46-0.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinecarboxamide, N-(phenylmethyl)-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinecarboxamide, N-(phenylmethyl)-, (2S)-(116774-46-0)
• EPA Substance Registry System: 2-Pyrrolidinecarboxamide, N-(phenylmethyl)-, (2S)-(116774-46-0)

Safety Data

• Hazardous Substances Data: 116774-46-0(Hazardous Substances Data)

Upstream product

• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 100-46-9 benzylamine 
• 147-85-3 L-proline 
• 3304-59-4 N-benzyloxycarbonyl-L-proline p-nitrophenyl ester 
• 7409-30-5 p-nitrobenzylamine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 3397-33-9 Z-proline N-hydroxysuccinimide ester 
• 64411-39-8 1-tert-butyl 2-phenyl pyrrolidine-1,2-dicarboxylate 
• 1393821-70-9 diphenylphosphine proline phenyl ester 
• 622-79-7 benzyl azide 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 141874-26-2 N-Boc-(S)-proline chloride 
• 121611-64-1 (S)-benzyl 2-(benzylcarbamoyl)pyrrolidine-1-carboxylate 
• 92235-33-1 (S)-tert-butyl 2-(benzylcarbamoyl)pyrrolidine-1-carboxylate 

Downstream Products

• 189107-17-3 (7aS,3S)-3-piperidino-1,2,5,6,7,7a-hexahydro-2-(phenylmethyl)pyrrolo<1,2-c><1,3,2>-diazaphosphole 3-oxide 
• 1281987-89-0 C₁₆H₂₄N₂O₂S 

Relevant articles and documents

Tetrahydropyrrole diamine-based bridged bisphenol rare earth metal complex as well as preparation method and application thereof

Ln Is a rare earth metal and a preparation method and an application thereof. R1 And R2 Is selected from tert-butyl, respectively. One of cumyl or triphenyl. The complex provided by the invention has the rare earth element and tetrahydropyrrole diamine base bridging ligand, can effectively catalyze ring opening reaction, and is high in reaction rate, high in activity and mild in reaction condition. The invention further provides a preparation method of the compound shown I. The invention also provides an application of the biodegradable high-molecular material polyhydroxybutyrate (PHB), the ring opening polymerization rate is improved, the preparation method is simpler and easier to control, the yield is high, and the cost is low.

Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts

Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group(IV) metal salts, and boron Lewis acids. The scope of the reaction was explored through the attempted synthesis of amides derived from twenty natural, and several unnatural, amino acids, as well as a wide selection of primary and secondary amines. The study also examines the synthesis of medicinally relevant compounds, and the scalability of this direct amidation approach. Finally, we provide insight into the chemoselectivity observed in these reactions.

[...] - Orn (ClCH2NH) - AA - benzylamine, its synthesis, activity and application (by machine translation)

The invention discloses the following formula of 13 for β - Carboline -3 - formyl - Orn (ClCH2 NH) - AA - NHCH2 C6 H5 (In the formula AA is selected from L - Arg, L - Asn, L - Asp, L - Glu, L - Gly, L - Ile, L - Leu, L - Met, L - Phe, L - Pro, L - Thr, L - Trp, L - Val residue), discloses a process for their preparation, discloses their inhibition of tumor cell growth, therefore this invention discloses their use as anti-tumor medicament. (by machine translation)