92235-33-1

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-
• CAS NO: 92235-33-1
• Molecular Formula: C17H24N2O3
• Molecular Weight: 304.389
• Mol File: 92235-33-1.mol
• Article Data: 39

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-(92235-33-1)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-[[(phenylmethyl)amino]carbonyl]-, 1,1-dimethylethyl ester, (2S)-(92235-33-1)

Safety Data

• Hazardous Substances Data: 92235-33-1(Hazardous Substances Data)

Upstream product

• 147-85-3 L-proline 
• 135097-23-3 (2S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 100-46-9 benzylamine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 35150-07-3 (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 
• 541-35-5 butanamide 
• 7531-52-4 L-prolinamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 141874-26-2 N-Boc-(S)-proline chloride 
• 135339-65-0 N^α,N,N-tris(tert-butoxycarbonyl)-(S)-prolinamide 

Downstream Products

• 116774-46-0 (S)-N-Benzylpyrrolidine-2-carboxyamide 
• 75773-76-1 (S)‐N‐benzyl‐1‐(pyrrolidin‐2‐yl) methanamine 
• 1281987-89-0 C₁₆H₂₄N₂O₂S 
• 1236255-21-2 L-proline benzylamide hydrochloride 
• 904326-08-5 (2S)-N-benzylpyrrolidine-2-carbothioamide 
• 914097-64-6 tert-butyl (2S)-2-(benzylthiocarbamoyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Synthetic method for preparing amide compounds through co-catalysis of niobium pentachloride and ionic liquid

The invention relates to a synthetic method for preparing amide compounds through co-catalysis of niobium pentachloride and ionic liquid. The preparation method is characterized by comprising the following steps: weighing organic carboxylic acid, organic amine, niobium pentachloride, ionic liquid and a molecular sieve, adding the materials into a reactor, adding an organic solvent, and reacting for 6-24 hours at the reaction temperature of 70-110 DEG C to obtain a corresponding amide product. The molar ratio of the organic carboxylic acid to the organic amine to the niobium pentachloride to the ionic liquid is 1:(1-3):(0.01-1):(0.05-1); wherein the mass ratio of the organic carboxylic acid to the molecular sieve is 1: (0.2-1). According to the method, the substrate range is expanded, the reaction yield is high (95% or above), the catalyst dosage is small, the atom economy is high, the catalyst is cheap and easy to obtain, the production cost can be greatly reduced, and the method is suitable for industrial production.

Air-stable Bis(pentamethylcyclopentadienyl) Zirconium Perfluorooctanesulfonate as an Efficient and Recyclable Catalyst for the Synthesis of N-substituted Amides

Bis(pentamethylcyclopentadienyl) zirconium perfluorooctanesulfonate is an air-stable and water-tolerant Lewis acid. This complex exhibited good thermal stability and high solubility in polar organic solvents. The compound showed relatively strong acidity, with an acid strength of 0.8Ho≤3.3, and high catalytic efficiency for the synthesis of N-substituted amides via the reaction of carboxylic acids with amines, the Ritter reaction of nitriles with alcohols, and the amination of alcohols with amides. Moreover, the complex had good reusability. This catalytic system affords a simple and efficient way to synthesize N-substituted amides.

[...] - Orn (ClCH2NH) - AA - benzylamine, its synthesis, activity and application (by machine translation)

The invention discloses the following formula of 13 for β - Carboline -3 - formyl - Orn (ClCH2 NH) - AA - NHCH2 C6 H5 (In the formula AA is selected from L - Arg, L - Asn, L - Asp, L - Glu, L - Gly, L - Ile, L - Leu, L - Met, L - Phe, L - Pro, L - Thr, L - Trp, L - Val residue), discloses a process for their preparation, discloses their inhibition of tumor cell growth, therefore this invention discloses their use as anti-tumor medicament. (by machine translation)