135097-23-3

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-
• Synonyms: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-;(S)-1-TERT-BUTYL 2-ETHYL PYRROLIDINE-1,2-DICARBOXYLATE
• CAS NO: 135097-23-3
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.29944
• Mol File: 135097-23-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 305.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.100±0.06 g/cm3(Predicted)
• PKA: -3.22±0.40(Predicted)
• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-(135097-23-3)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)-(135097-23-3)

Safety Data

• Hazardous Substances Data: 135097-23-3(Hazardous Substances Data)

Usage

Derivative of

Pyrrolidine carboxylic acid

Common use

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Chirality

Chiral molecule with a distinct three-dimensional structure

Enantiomerically pure compounds

Often used in the production of enantiomerically pure compounds

Applications

Organic chemistry and drug development

Structural properties

Unique structural properties and stereochemistry

Stereochemistry

(2S)configuration, indicating the arrangement of atoms in the molecule

Functional groups

Contains carboxylic acid, ester, and tertiary amine groups

Solubility

Likely soluble in organic solvents such as ethanol, methanol, or acetone, due to its nonpolar nature

Stability

Stable under normal conditions, but sensitive to heat, light, and moisture

Reactivity

May react with nucleophiles, acids, and bases, depending on the reaction conditions and reagents used

Purity

Often requires purification through techniques such as column chromatography or recrystallization to ensure enantiomeric purity

Safety

Handle with care, as it may have potential hazards depending on its use and concentration

Storage

Store in a cool, dry, and well-ventilated area, away from heat, light, and moisture, in a sealed container to maintain stability and purity

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 75-03-6 ethyl iodide 
• 194594-23-5 5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 33305-75-8 L-proline ethyl ester monohydrochloride 
• 64-17-5 ethanol 
• 147-85-3 L-proline 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 5817-26-5 ethyl (2S)-pyrrolidine-2-carboxylate 

Downstream Products

• 94459-10-6 2-(2,4-Dimethoxy-benzyl)-1-oxo-2,5-diaza-spiro[3.4]octane-5-carboxylic acid tert-butyl ester 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 69610-41-9 Boc-L-Pro-H 
• 160115-24-2 (2S)-2-((dimethylamino)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1152113-36-4 N,N-dimethyl-N-(((2S)-pyrrolidin-2-yl)methyl)amine dihydrochloride 
• 174195-98-3 (S)-1'-(pyrrolidin-2-yl)cyclopentanol 
• 60261-46-3 (2S)-2-[(diphenylphosphino)methyl]pyrrolidine 
• 130203-12-2 (S)-1-Cyclohex-1-enyl-2-[(diphenylphosphanyl)-methyl]-pyrrolidine 
• 130203-11-1 (S)-2-[(Diphenylphosphanyl)-methyl]-1-((Z)-2-phenyl-propenyl)-pyrrolidine 
• 130203-07-5 (E)-3-{(S)-2-[(Diphenylphosphanyl)-methyl]-pyrrolidin-1-yl}-2-methyl-but-2-enoic acid ethyl ester 
• 130203-08-6 (E)-3-{(S)-2-[(Diphenylphosphanyl)-methyl]-pyrrolidin-1-yl}-2-methyl-but-2-enoic acid tert-butyl ester 
• 135055-77-5 (S)-2-[(Diphenylphosphanyl)-methyl]-1-((E)-2-methyl-but-1-enyl)-pyrrolidine 
• 135055-75-3 (S)-(-)-N-tert-butoxycarbonyl-2-<(diphenylphosphino)methyl>pyrrolidine 
• 135055-76-4 (S)-1-[(E)-3-(4-tert-Butyl-phenyl)-2-methyl-propenyl]-2-[(diphenylphosphanyl)-methyl]-pyrrolidine 

Relevant articles and documents

ANTIVIRAL COMPOUNDS

The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.

Cobalt-Catalyzed Esterification of Amides

The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol %.

One-pot transformation of carboxylic acids into nitriles

A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with ethyl iodide/K2CO3/18-crown-6, followed by sodium diisobutyl-tert-butoxyaluminium hydride (SDBBA-H), and finally treatment with molecular iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH), and aqueous ammonia. This method is useful for the conversion of various aromatic and aliphatic carboxylic acids into the corresponding nitriles in a one-pot procedure. A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with ethyl iodide/K2CO3/18-crown-6, followed by sodium diisobutyl-tert-butoxyaluminium hydride (SDBBA-H), and finally treatment with molecular iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH), and aqueous ammonia. Copyright