116965-16-3 Usage
Description
3-Nitro-4-(trifluoromethyl)benzoic acid is an organic compound characterized by its white to light yellow crystal powder appearance. It is a derivative of benzoic acid with a nitro group at the 3-position and a trifluoromethyl group at the 4-position, which contributes to its unique chemical properties and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
3-Nitro-4-(trifluoromethyl)benzoic acid is used as a key intermediate in the synthesis of trifluoromethylated (benzoxazolyl)actinocins. These compounds are of significant interest due to their potential therapeutic properties, particularly in the development of novel antibiotics and other medicinal agents. The trifluoromethyl group imparts enhanced lipophilicity and metabolic stability to the molecules, which can lead to improved bioavailability and efficacy.
Used in Chemical Synthesis:
In the field of organic chemistry, 3-nitro-4-(trifluoromethyl)benzoic acid can be utilized as a versatile building block for the creation of a wide range of chemical compounds. Its unique functional groups allow for various synthetic transformations, making it a valuable precursor in the development of new molecules with potential applications in materials science, agrochemistry, and other areas.
Used in Research and Development:
3-Nitro-4-(trifluoromethyl)benzoic acid is also employed in research and development settings, where it can be used to study the effects of structural modifications on the properties and reactivity of benzoic acid derivatives. This knowledge can be applied to the design of new compounds with tailored properties for specific applications, such as improved drug candidates or advanced materials with unique characteristics.
Check Digit Verification of cas no
The CAS Registry Mumber 116965-16-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,9,6 and 5 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 116965-16:
(8*1)+(7*1)+(6*6)+(5*9)+(4*6)+(3*5)+(2*1)+(1*6)=143
143 % 10 = 3
So 116965-16-3 is a valid CAS Registry Number.
InChI:InChI=1/C2HBr2F3/c3-1(5)2(4,6)7/h1H/t1-/m0/s1
116965-16-3Relevant articles and documents
2-nitro-4-trifluoromethyl-benzoic acid and preparation method of isomer thereof
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Paragraph 0037; 0039; 0041; 0043; 0045; 0047; 0049-0055, (2018/10/19)
The invention discloses a 2-nitro-4-trifluoromethyl-benzoic acid and a preparation method of an isomer thereof, belongs to the technical field of organic synthesis, and solves the problems that in theprior art, raw materials for preparing a 2-nitro-4-trifluoromethyl-benzoic acid and the isomer thereof are expensive and the yield is slightly low. In order to solve the problems, the invention provides the 2-nitro-4-trifluoromethyl-benzoic acid and the preparation method of the isomer thereof. The preparation method comprises the following steps: with 4-(trifluoromethyl)benzonitrile as a raw material, performing a one-step reaction under the effect of a nitrating agent to obtain the 2-nitro-4-trifluoromethyl-benzoic acid and a 3-nitro-4-trifluoromethyl-benzoic acid. The preparation method has the advantages that the 2-nitro-4-trifluoromethyl-benzoic acid and the isomer thereof can be obtained only through the one-step reaction, the operation is simple and convenient, the reaction steps are short, the yield is high, and the 2-nitro-4-trifluoromethyl-benzoic acid and the isomer thereof are suitable for industrialized production.
SUBSTITUTED PYRAZOLES, COMPOSITIONS AND USE
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, (2008/06/13)
Substituted pyrazole compounds are angiotensin II antagonists and therefore useful in the treatment of hypertension, and related cardiovascular disorders and ocular hypertension. These compounds have the general formula I: STR1
