117354-64-0 Usage
Description
2-Hydroxysaclofen is a chemical compound that functions as a GABA-B receptor antagonist, primarily in the ventral tegmental area. It has been found to influence the mechanisms of cocaine usage and affect specific acute nicotine responses in mice.
Used in Pharmaceutical Applications:
2-Hydroxysaclofen is used as a GABA-B receptor antagonist for its potential role in understanding and treating substance abuse, particularly cocaine and nicotine addiction. It modulates the effects of these substances on the brain by targeting the GABA-B receptors, which are involved in the reward system and addictive behaviors.
Used in Research and Development:
In the field of neuroscience and pharmacology, 2-Hydroxysaclofen is used as a research tool to study the effects of GABA-B receptor modulation on various behaviors and responses, such as hypolocomotion and antinociception in mice. This helps researchers gain insights into the underlying mechanisms of addiction and potential therapeutic approaches.
Used in Drug Discovery and Development:
2-Hydroxysaclofen serves as a starting point for the development of new drugs targeting GABA-B receptors, which could potentially be used in the treatment of substance abuse disorders and other conditions related to the GABAergic system. Its unique properties make it a valuable compound for further research and drug design.
Biological Activity
Selective antagonist at GABA B receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 117354-64-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,3,5 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 117354-64:
(8*1)+(7*1)+(6*7)+(5*3)+(4*5)+(3*4)+(2*6)+(1*4)=120
120 % 10 = 0
So 117354-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)/t9-/m1/s1
117354-64-0Relevant articles and documents
The Synthesis of (R)-(-) and (S)-(+)-Hydroxysaclofen
Prager, Rolf H.,Schafer, Karl,Hamon, David P. G.,Massy-Westropp, Ralph A.
, p. 11465 - 11472 (2007/10/02)
2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide.The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen.Only the latter showed activity as a specific GABAB antagonist.
Synthesis of 3-Amino-2-(4-chlorophenyl)propanesulfonic Acid (Saclofen) and 3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic Acid (Hydroxysaclofen)
Abbenante, Giovanni,Prager, Rolf H.
, p. 213 - 214 (2007/10/02)
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