117653-36-8

Basic information

• Product Name: methyl (2S,4E)-1-(benzyloxycarbonyl)-4-(2-tert-butoxy-2-oxoethylidene)-2-pyrrolidinecarboxylate
• Synonyms: methyl (2S,4E)-1-(benzyloxycarbonyl)-4-(2-tert-butoxy-2-oxoethylidene)-2-pyrrolidinecarboxylate
• CAS NO: 117653-36-8
• Molecular Weight: 375.422
• Mol File: 117653-36-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl (2S,4E)-1-(benzyloxycarbonyl)-4-(2-tert-butoxy-2-oxoethylidene)-2-pyrrolidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,4E)-1-(benzyloxycarbonyl)-4-(2-tert-butoxy-2-oxoethylidene)-2-pyrrolidinecarboxylate(117653-36-8)
• EPA Substance Registry System: methyl (2S,4E)-1-(benzyloxycarbonyl)-4-(2-tert-butoxy-2-oxoethylidene)-2-pyrrolidinecarboxylate(117653-36-8)

Safety Data

• Hazardous Substances Data: 117653-36-8(Hazardous Substances Data)

Upstream product

• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 
• 41108-81-0 tert-butyl (trimethylsilyl)acetate 
• 16217-15-5 1-benzyloxycarbonyl-4-oxo-L-proline methyl ester 

Downstream Products

• 934006-98-1 (2S,4R)-1-(tert-butoxycarbonyl)-4-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1,2-pyrrolidinecarboxylic acid 
• 168034-52-4 methyl (2S,4S)-4-<(menthyloxycarbonyl)methyl>pyrrolidine-2-carboxylate 
• 168112-50-3 methyl (2S,4R)-4-<(menthyloxycarbonyl)methyl>pyrrolidine-2-carboxylate 
• 147235-94-7 (2S,4S)-4-(carboxymethyl)pyrrolidine-2-carboxylic acid 
• 147235-94-7 (2S,4R)-4-(carboxymethyl)pyrrolidine-2-carboxylic acid 
• 168034-47-7 (2S,4R)-4-tert-Butoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Relevant articles and documents

Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration

A series of 5β-methylprolyl-2-cyanopyrrolidine analogs were synthesized and evaluated as DPP-IV inhibitors, and the duration of their ex vivo activity was assessed. Comparison of their potency and duration of action was done among three different species.

Amino Acid Derivatives That Stabilize Secondary Structures of Polypeptides. 4. Practical Synthesis of 4-(Alkylamino)-3-cyano-6-azabicyclooct-3-enes (Ben Derivatives) as γ-Turn Templates

A practical synthesis of the conformationally restricted amino acid analogue methyl N-oct-2-enyl>>-L-alaninate (12ab) from 4-hydroxyproline is described.Blocking and Barton cyanoethylation generates N-(