117710-72-2Relevant articles and documents
Selective Reductions. 52. Efficient Asymmetric Reduction of α-Acetylenic α'-Fluoroalkyl Ketones with Either B-Chlorodiisopinocampheylborane or B-Isopinocampheyl-9-borabicyclononane in High Enantiomeric Purity. The Influence of Fluoro Groups in Such
Ramachandran, P. Veeraraghavan,Gong, Baoqing,Teodorovic, Aleksandar V.,Brown, Herbert C.
, p. 1061 - 1074 (1994)
A systematic study of the asymmetric reduction of prochiral α-acetylenic α'-fluoroalkyl ketones with (-)-B-chlorodiisopinocampheylborane and (-)-B-isopinocampheyl-9-borabicyclononane (R-Alpine-Borane, 2) reveals that perfluoro
Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent
Miele, Margherita,Citarella, Andrea,Micale, Nicola,Holzer, Wolfgang,Pace, Vittorio
supporting information, p. 8261 - 8265 (2019/10/16)
The homologation of Weinreb amides into difluoromethylketones with a formal nucleophilic CHF2 transfer agent is reported. Activating TMSCHF2 with potassium tert-amylate enables a convenient access to the difluorinated homologation re
Stereoselective synthesis of anti-α-(difluoromethyl)-β-amino alcohols by boronic acid based three-component condensation. Stereoselective preparation of (2S,3R)-difluorothreonine
Prakash, G. K. Surya,Mandal, Mihirbaran,Schweizer, Stefan,Petasis, Nicos A.,Olah, George A.
, p. 3718 - 3723 (2007/10/03)
Starting from optically active 3,3-difluorolactaldehyde, an alkenyl or aryl boronic acid, and an amine, a one-step three-component methodology was developed for the stereoselective preparation of anti-α-(difluoromethyl)-β-amino alcohols. β-Furyl-substituted anti-α-(difiuoromethyl)-β-amino alcohol was further elaborated to form (2S,3R)-difluorothreonine in high yield and ee.