1181226-25-4

Basic information

• Product Name: clitocybin C
• Synonyms: clitocybin C
• CAS NO: 1181226-25-4
• Molecular Weight: 285.299
• Mol File: 1181226-25-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: clitocybin C(CAS DataBase Reference)
• NIST Chemistry Reference: clitocybin C(1181226-25-4)
• EPA Substance Registry System: clitocybin C(1181226-25-4)

Safety Data

• Hazardous Substances Data: 1181226-25-4(Hazardous Substances Data)

Upstream product

• 52344-93-1 methyl 2-formyl-3,5-dimethoxybenzoate 
• 123-30-8 4-amino-phenol 

Downstream Products

• 1086908-58-8 clitocybin A 
• 1181226-24-3 clitocybin B 

Relevant articles and documents

Synthesis of Clitocybin A, B and C and their Biological Evaluation for Antioxidant Activities

Clitocybin A, isolated from the culture broth of mushroom Clitocybe aurantiaca, showed various biological activities such as cell death inhibition effects, anti-wrinkle effects, aortic smooth muscle cell proliferation inhibition effects. In an effort to further develop this promising compound toward a potent antioxidant, we have modified the structure of clitocybin A by changing the number of free phenolic hydrogen in isoindolinone moiety. In this paper, clitocybin A and its analogues, clitocybin B and C were synthesized and their antioxidant activities were evaluated. Clitocybin A possessing two phenolic hydrogens in isoindolinone moiety of clitocybin A analogues showed more potent radical scavenging activity than clitocybin B possessing one phenolic hydrogen. In inhibition of cellular DNA damage in H2O2treated cells, clitocybin C lacking free phenolic hydrogen in isoindolinone moiety showed more potent activity than clitocybin A possessing two phenolic hydrogens.Among the tested compounds, clitocybin A only showed dose-dependently HNE inhibitory activity with an IC50 value of 78.8 uM. The presence of free phenolic hydrogens inisoindolinone moiety of clitocybin A analogues plays an important role in antioxidant activities.

NOVEL CLITOCYBIN DERIVATIVES, PREPARATION METHOD THEREOF AND COMPOSITION CONTAINING THE EXTRACT OF CLITOCYBE AURANTIACA KCTC 11143BP OR THE NOVEL CLITOCYBIN DERIVATIVES FOR PREVENTION OF AGING AS AN ACTIVE INGREDIENT

Disclosed are novel clitocybin derivatives and methods for the preparation thereof. Also, anti-aging, pharmaceutical or cosmetic composition comprising the clitocybin derivatives as active ingredient are also provided. The extract from Clitocybe aurantiaca (KCTC 11143BP) or the novel clitocybin derivatives have excel lent ability to scavenge oxygen radicals, to inhibit oxidative DNA damage and to reduce UV-induced erythema, so that they can be useful in the prophylaxis and treatment of diseases attributable to the accumulation of excess active oxygen and can be applied to the preparation of pharmaceutical or cosmetic compositions for the prevention of aging.