118149-31-8

Basic information

• Product Name: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate
• Synonyms: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate
• CAS NO: 118149-31-8
• Molecular Weight: 906.904
• Mol File: 118149-31-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate(118149-31-8)
• EPA Substance Registry System: 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate(118149-31-8)

Safety Data

• Hazardous Substances Data: 118149-31-8(Hazardous Substances Data)

Upstream product

• 1196870-93-5 5'-O-dimethoxytritylthymidine-3'-O-(2-oxo-1,3,2-dithiaphospholane) 
• 21090-30-2 3'-O-acetylthymidine 
• 184773-07-7 C₅₀H₅₁ClN₅O₁₆PS 
• 129789-72-6 C₅₀H₅₁Cl₂N₄O₁₄PS 
• 189153-43-3 C₄₉H₅₂N₅O₁₅PS 
• 184773-08-8 C₄₈H₅₃N₆O₁₄PS 
• 189153-40-0 C₅₀H₅₂N₅O₁₆PS 
• 189153-44-4 C₄₉H₅₅N₆O₁₅PS 
• 189153-42-2 C₄₉H₅₁ClN₅O₁₄PS 
• 189153-41-1 C₄₉H₅₂N₅O₁₄PS 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 127088-91-9 triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate 
• 118149-23-8 O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) N,N-diisopropylphosphoramidite 
• 104655-84-7 5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite 

Downstream Products

• 92127-24-7 C₄₁H₄₅N₄O₁₃PS 

Relevant articles and documents

Chemoselective synthesis of dithymidine phosphorothioate in solution using O-protected thiophosphate monomers

Diastereomerically pure O-protected thymine monothioate nucleotide (I) is efficiently coupled to protected thymidine (II) in a chemoselective, but not stereoselective manner, to give dithymidine phosphorothioates (III).

O-Methyl-bis-O-(4-nitrophenyl)phosphite: a novel chemoselective O-phosphitylating reagent

A novel chemoselective O-phosphitylating reagent containing two aryloxy leaving groups at a P(III) center is developed for selective formation of P(III) esters from amino alcohols without the need to protect the amino group. The reagent proved to be highl

A new strategy for the synthesis of phosphorothioates of 2′-deoxyriboligonucleotides

2-Picoline thiol, a new reagent, has been indigenously prepared and a new strategy has been followed for the sulphurization of phosphate bond in nucleotide monomer. The 2-picolylthiophosphorobis-(triazolide) has been prepared using phosphite triester approach and treated with protected nucleosides to get phosphorothioate synthons. The two dimers, d(GpT) and d(TpT) have been synthesised in very good yields using these synthons. The removal of 2-methylpyridyl group at the end of synthesis is achieved with 1,1,3,3-tetramethylguanidinium-4-nitrobenzaldoxime in dioxane-water.