92127-24-7Relevant articles and documents
Large-scale synthesis of oligpnucleotide phosphorothioates using 3-amino-1,2,4-dithiazole-5-thione as an efficient sulfur-transfer reagent
Tang, Jin-Yan,Han, Yongxin,Tang, Jimmy X.,Zhang, Zhaoda
, p. 194 - 198 (2000)
A commercially available and inexpensive compound, 3-amino-1,2,4-dithiazole-5-thione (ADTT), is discovered to be a new sulfur-transfer reagent for solid-phase synthesis of oligonucleotide phosphorothioates via the phosphoramidite method. The efficiency of ADTT was investigated by solid-phase syntheses of dinucleotide and oligonucleotide phosphorothioates. The results show that ADTT is a highly efficient sulfur-transfer reagent and fully compatible with automated solid-phase synthesis. ADTT has been applied in manufacture of oligonucleotide phosphorothioates to reduce the cost significantly.
SULFUR TRANSFER REAGENTS FOR OLIGONUCLEOTIDE SYNTHESIS
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Page/Page column 5, (2009/12/24)
The use of N-formamidino-5-amino-3H-1,2,4-dithiazole-3-thiones as novel, efficient sulfur-transfer reagents is disclosed. The sulfur transfer from these reagents to compounds containing P(III) atom, triphenylphosphine, 5′-O-DMT-thymidine 2-cyanoethyl-(N,N
O-2,4-DICHLOROPHENYL S-METHYL PHOSPHOROCHLORIDOTHIOATE: A VERSATILE AGENT IN THE FORMATION OF THE 3'-5' INTERNUCLEOTIDIC LINKAGE BY THE PHOSPHOTRIESTER APPROACH TO OLIGONUCLEOTIDE SYNTHESIS
Caruso, Pier Bartolomeo,Sindona, Giovanni,Liguori, Angelo,Uccella, Nicola
, p. 253 - 256 (2007/10/02)
O-2,4-dichlorophenyl S-methyl phosphorochloridothioate can be used as a phosphorylating agent in the formation of (3'-5') dinucleoside phosphates and phosphorothioates.The former have beeen obtained by removal of the methylthio function from the protected
