118248-44-5Relevant articles and documents
Efficient resolution of racemic N-benzyl β3-amino acids by iterative liquid-liquid extraction with a chiral (salen)cobalt(iii) complex as enantioselective selector
Dzygiel, Pawel,Monti, Chiara,Piarulli, Umberto,Gennari, Cesare
, p. 3464 - 3471 (2007)
The efficient (up to 93% ee) resolution of racemic N-benzyl β3-amino acids has been achieved by an iterative (two cycle) liquid-liquid extraction process using a lipophilic chiral (salen)cobalt(iii) complex [CoIII(1)(OAc)]. As a result of the resolution by extraction, one enantiomer of the N-benzyl β3-amino acid predominated in the aqueous phase, while the other enantiomer was driven into the organic phase by complexation to cobalt. The complexed amino acid was then quantitatively released into an aqueous phase, by a reductive (CoIII → Co II) counter-extraction using l-ascorbic acid. The reductive cleavage allowed for the recovery of the cobalt(ii) selector in up to 90% yield (easily re-oxidable to CoIII with air/AcOH). The Royal Society of Chemistry.
Process for producing either optically active n-substituted beta-amino acid and optically active n-substituted beta-amino acid ester or optically active n-substituted 2-homopipecolic acid and optically active n-substituted 2-homopipecolic acid ester
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, (2008/06/13)
The present invention discloses a process which comprises selectively hydrolyzing one enantiomer of racemic mixtures of an N-substituted β-amino acid alkyl ester or N-substituted 2-homopipecolic acid ester represented by the formula (I): wherein Ar, Rsup
