118248-45-6

Basic information

• Product Name: 4-isopropyl-1-benzylazetidin-2-one
• Synonyms: 4-isopropyl-1-benzylazetidin-2-one
• CAS NO: 118248-45-6
• Molecular Weight: 203.284
• Mol File: 118248-45-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-isopropyl-1-benzylazetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-isopropyl-1-benzylazetidin-2-one(118248-45-6)
• EPA Substance Registry System: 4-isopropyl-1-benzylazetidin-2-one(118248-45-6)

Safety Data

• Hazardous Substances Data: 118248-45-6(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 118248-44-5 ethyl (rac)-3-benzylamino-4-methylpentanoate 
• 347406-30-8 3,3-dichloro-4-[(1-chloro-1-methyl)ethyl]-1-benzylazetidin-2-one 
• 118248-61-6 (rac)-3-benzylamino-4-methylpentanoic acid 

Downstream Products

• 7486-92-2 4-isopropylazetidin-2-one 
• 118248-48-9 (3RS,4RS)-3-(3-butenyl)-4-isopropylazetidin-2-one 

Relevant articles and documents

Metal-catalysed radical cyclisations leading to N-heterocycles: New approaches to gabapentin and pulchellalactam

The copper(I) or ruthenium(II)-mediated radical cyclisation of halo-amides has been utilised to afford functionalised pyrrolidinones via 5-endo-trig or 5-exo-trig radical cyclisation pathways. This methodology has been applied to novel and concise syntheses of the anti-epileptic drug gabapentin and the biologically active natural product pulchellalactam.

A Convenient Method for β-Lactam Formation from β-Amino Acids using Diphenylphosphinic Chloride

Diphenylphosphinic chloride is found to be very effective in promoting β-lactam formation from β-amino acids.