118304-63-5Relevant articles and documents
Synthesis of New Aromatic Retinoid Analogues by Low-Valent Titanium Induced Reductive Elimination
Solladie, Guy,Girardin, Andre,Lang, Gerard
, p. 2620 - 2628 (2007/10/02)
The low-valent titanium reductive elimination reaction, already applied to the stereospecific synthesis of vitamin A and 13-cis-retinol, was used to prepare several retinoic acid analogues in the all-trans configuration or in the 13-cis configuration.This highly stereospecific trans-diene formation allowed an improved synthesis of the title compounds without any purification of the intermediates before the final stage.