118353-48-3

Basic information

• Product Name: [(1R,2S,4R)-6-Benzenesulfonyl-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-tert-butyl-dimethyl-silane
• CAS NO: 118353-48-3
• Molecular Weight: 619.039
• Mol File: 118353-48-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [(1R,2S,4R)-6-Benzenesulfonyl-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-tert-butyl-dimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R,2S,4R)-6-Benzenesulfonyl-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-tert-butyl-dimethyl-silane(118353-48-3)
• EPA Substance Registry System: [(1R,2S,4R)-6-Benzenesulfonyl-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-tert-butyl-dimethyl-silane(118353-48-3)

Safety Data

• Hazardous Substances Data: 118353-48-3(Hazardous Substances Data)

Upstream product

• 118299-05-1 (2E)-2,3-Dideoxy-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-enonic acid methyl ester 
• 126502-51-0 (2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene 
• 126502-48-5 (2E)-2,3-Dideoxy-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-enitol 
• 126502-49-6 (2E)-2,3-Dideoxy-1-chloro-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene 
• 126502-52-1 (E)-(5S,6R,7S)-6-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5,7-dimethoxy-3-methyl-hept-3-enal 
• 118299-04-0 2,4-Di-O-methyl-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-D-galactose 
• 126502-46-3 2,4-Di-O-methyl-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-D-galactol 
• 126502-45-2 2,4-Di-O-methyl-3-O-(phenylmethyl)-D-galactol 
• 126502-53-2 (E)-(2R,3S,4R,5S)-3,5-Dimethoxy-7-methyl-non-6-ene-1,2,4,9-tetraol 
• 118299-10-8 Benzoic acid (3E,8E)-(5S,6R,7S)-6-hydroxy-5,7-dimethoxy-9-methoxycarbonyl-3-methyl-deca-3,8-dienyl ester 
• 118299-05-1 (E)-(4S,5R,6S)-5-Benzyloxy-6-(2,2-dimethyl-[1,3]dioxolan-4-yl)-4,6-dimethoxy-2-methyl-hex-2-enoic acid methyl ester 
• 126502-51-0 (E)-(5S,6R,7S)-6-Benzyloxy-7-(2,2-dimethyl-[1,3]dioxolan-4-yl)-5,7-dimethoxy-3-methyl-hept-3-enenitrile 
• 126502-48-5 (E)-(4S,5R,6S)-5-Benzyloxy-6-(2,2-dimethyl-[1,3]dioxolan-4-yl)-4,6-dimethoxy-2-methyl-hex-2-en-1-ol 
• 126502-49-6 4-((E)-(1S,2R,3S)-2-Benzyloxy-6-chloro-1,3-dimethoxy-5-methyl-hex-4-enyl)-2,2-dimethyl-[1,3]dioxolane 

Downstream Products

• 127492-54-0 C₇₄H₁₃₀O₁₂S₃Si₃ 

Relevant articles and documents

Stereoselective routes to the C10-C19 fragment of FK-506

D-Galactose was used as a starting material to reach the titled system. The key elements of one of the syntheses involved directed homogeneous hydrogenation and diastereoselective lactonization reactions (see 26 → 6 and 6 → 7). In another synthetic route directed catalytic hydrogenation was used to fashion 34 where the end groups were already differentiated.

Studies relating to the synthesis of the immunosuppressive agent FK-506: Application of the two-directional chain synthesis strategy to the pyranose moiety

-