126502-49-6

Basic information

• Product Name: 4-((E)-(1S,2R,3S)-2-Benzyloxy-6-chloro-1,3-dimethoxy-5-methyl-hex-4-enyl)-2,2-dimethyl-[1,3]dioxolane
• Synonyms: 4-((E)-(1S,2R,3S)-2-Benzyloxy-6-chloro-1,3-dimethoxy-5-methyl-hex-4-enyl)-2,2-dimethyl-[1,3]dioxolane
• CAS NO: 126502-49-6
• Molecular Weight: 398.927
• Mol File: 126502-49-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-((E)-(1S,2R,3S)-2-Benzyloxy-6-chloro-1,3-dimethoxy-5-methyl-hex-4-enyl)-2,2-dimethyl-[1,3]dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((E)-(1S,2R,3S)-2-Benzyloxy-6-chloro-1,3-dimethoxy-5-methyl-hex-4-enyl)-2,2-dimethyl-[1,3]dioxolane(126502-49-6)
• EPA Substance Registry System: 4-((E)-(1S,2R,3S)-2-Benzyloxy-6-chloro-1,3-dimethoxy-5-methyl-hex-4-enyl)-2,2-dimethyl-[1,3]dioxolane(126502-49-6)

Safety Data

• Hazardous Substances Data: 126502-49-6(Hazardous Substances Data)

Upstream product

• 118299-05-1 (E)-(4S,5R,6S)-5-Benzyloxy-6-(2,2-dimethyl-[1,3]dioxolan-4-yl)-4,6-dimethoxy-2-methyl-hex-2-enoic acid methyl ester 
• 118299-04-0 (2R,3S,4S)-3-Benzyloxy-4-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4-dimethoxy-butyraldehyde 
• 126502-46-3 (2S,3R,4S)-3-Benzyloxy-4-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,4-dimethoxy-butan-1-ol 
• 126502-45-2 (3S,4R,5S)-4-Benzyloxy-3,5-dimethoxy-hexane-1,2,6-triol 
• 126502-48-5 (E)-(4S,5R,6S)-5-Benzyloxy-6-(2,2-dimethyl-[1,3]dioxolan-4-yl)-4,6-dimethoxy-2-methyl-hex-2-en-1-ol 
• 118299-05-1 (2E)-2,3-Dideoxy-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-enonic acid methyl ester 
• 118299-04-0 2,4-Di-O-methyl-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-D-galactose 
• 126502-46-3 2,4-Di-O-methyl-5,6-O-(1-methylethylidene)-3-O-(phenylmethyl)-D-galactol 
• 126502-45-2 2,4-Di-O-methyl-3-O-(phenylmethyl)-D-galactol 
• 126502-48-5 (2E)-2,3-Dideoxy-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-enitol 

Downstream Products

• 118353-48-3 [(1R,2S,4R)-6-Benzenesulfonyl-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-tert-butyl-dimethyl-silane 
• 118299-16-4 <1R-<1R*,(1S*,3R*),2S*,4R*>>-(1,1-Dimethylethyl)<<1-<3-(1,3-dithian-2-yl)-1-methoxybutyl>-2-methoxy-4-methyl-6-(phenylsulfonyl)hexyl>oxy>dimethylsilane 
• 118299-15-3 <γS-(γR*,εR*,ξS*,ηR*,ιS*)>-ξ-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-ε,η-dimethoxy-γ,ι-dimethyl-1,3-dithiane-2-nonanol-benzoate 
• 118299-07-3 (3E)-2,3,4-Trideoxy-3-methyl-5,7-di-O-methyl-8,9-O-(1-methylethylidene)-6-O-(phenylmethyl)-D-galacto-non-3-enitol 
• 118299-11-9 <2R-(2R*,4S*,5R*,8S*)>-10-(Benzoyloxy)-5-hydroxy-4,6-dimethoxy-2,8-dimethyldecanoic acid methyl ester 
• 118299-14-2 <3S-(3R*,5R*,6R*,7R*,9R*)>-9-(1,3-Dithian-2-yl)-5,7-dimethoxy-3-methyl-1,6-decanediol 1-benzoate 
• 126502-52-1 (E)-(5S,6R,7S)-6-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5,7-dimethoxy-3-methyl-hept-3-enal 
• 118299-12-0 <3R-<3α,5α,6β(1S*,3S*)>>-6-<5-(Benzoyloxy)-1-methoxy-3-methylpentyl>tetrahydro-5-methoxy-3-methyl-2H-pyran-2-one 
• 118299-13-1 <2R-<2α(γS*,εS*),3β,5β,6α/β>>-6-Hydroxy-ε,3-dimethoxy-γ,5-dimethyltetrahydro-2H-pyran-2-pentanol benzoate 
• 118299-10-8 Benzoic acid (3E,8E)-(5S,6R,7S)-6-hydroxy-5,7-dimethoxy-9-methoxycarbonyl-3-methyl-deca-3,8-dienyl ester 
• 126502-51-0 (E)-(5S,6R,7S)-6-Benzyloxy-7-(2,2-dimethyl-[1,3]dioxolan-4-yl)-5,7-dimethoxy-3-methyl-hept-3-enenitrile 
• 126502-50-9 (E)-(5S,6R,7S)-6-Benzyloxy-7-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5,7-dimethoxy-3-methyl-hept-2-enenitrile 
• 126502-51-0 (2E)-2,3-Dideoxy-1-cyano-2-methyl-4,6-di-O-methyl-7,8-O-(1-methylethylidene)-5-O-(phenylmethyl)-D-galacto-oct-2-ene 

Relevant articles and documents

Stereoselective routes to the C10-C19 fragment of FK-506

D-Galactose was used as a starting material to reach the titled system. The key elements of one of the syntheses involved directed homogeneous hydrogenation and diastereoselective lactonization reactions (see 26 → 6 and 6 → 7). In another synthetic route directed catalytic hydrogenation was used to fashion 34 where the end groups were already differentiated.