118388-50-4Relevant articles and documents
Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites
Kaltenbronn,Hudspeth,Lunney,Michniewicz,Nicolaides,Repine,Roark,Stier,Tinney,Woo,Essenburg
, p. 838 - 845 (2007/10/02)
Renin inhibitors having 13 different isosteres connecting the P3 and P2 positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai