73058-30-7Relevant articles and documents
Synthesis method of (D)-2-benzyl-N,N-dimethylaziridine-1-sulfonamide
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, (2020/08/27)
The invention discloses a synthesis method of (D)-2-benzyl-N,N-dimethylaziridine-1-sulfonamide, which comprises the following steps: a. reducing D-phenylalanine to obtain D-phenylalaninol, b. performing esterification and ring-closing reactions on the D-phenylalaninol to obtain (D)-2-benzyl-N,N-dimethylaziridine; and c. carrying out a reaction on the (D)-2-benzyl-N,N-dimethylaziridine with dimethylamino sulfonyl chloride to generate the (D)-2-benzyl-N,N-dimethyl aziridine-1-sulfonamide. The product has high content and purity, enhances the yield of industrial production, shortens the half timeof industrial production, and effectively considers the problems of environmental protection, cost and yield.
Efficient Direct Synthesis of Aziridine-Containing Chiral Tridentate Ligands by the Iminium-Mediated Self-Ring Opening Reaction of Enantiopure Aziridines and Salicylaldehydes
Chen, Xingpeng,Lin, Chao,Du, Hongguang,Xu, Jiaxi
, p. 1647 - 1661 (2019/02/27)
An efficient method for the direct synthesis of aziridine-containing chiral tridentate ligands was developed from enantiopure aziridines and salicylaldehydes. The method achieved the regiospecific cleavage of more substituted C?N bonds of aziridines through an iminium-mediated self-ring opening reaction of aziridines with up to 95% yield and complete inversion of configuration. The (S)-2-alkylaziridine-derived tridentate ligands displayed excellent activity and stereoselectivity in the zinc trifluoromethanesulfonate-catalyzed asymmetric aldol reactions of acetone and aromatic aldehydes. (Figure presented.).
Synthesis of novel N-protected β3-amino nitriles: study of their hydrolysis involving a nitrilase-catalyzed step
Veitia, Maite Sylla-Iyarreta,Brun, Pierre Louis,Jorda, Pierre,Falguieres, Annie,Ferroud, Clotilde
experimental part, p. 2077 - 2089 (2010/03/04)
Several commercially available nitrilases were investigated with regard to their potential to hydrolyze N-protected β3-amino nitriles into their corresponding N-protected β3-amino acids. The biotransformations were obtained in different proportions depending on the nitrilase involved. The best hydrolysis results were achieved for the N-Cbz-β3-amino nitrile from l-alanine using the NIT-107, in a phosphate buffer at 0.05 M. However, no biotransformation into the corresponding acids was observed for the N-sulfonylamide β3-amino nitriles. Two simple and efficient procedures to prepare the β3-amino nitriles from their analogous α-amino acids are described. Thirty four new substances were synthesized and characterized over the course of this work.