1184-20-9

Basic information

• Product Name: (4R)-Methyl 4-((3R,5R,6S,10R,13R,17R)-10,13-diMethyl-3,6-bis(tosyloxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
• Synonyms: (4R)-Methyl 4-((3R,5R,6S,10R,13R,17R)-10,13-diMethyl-3,6-bis(tosyloxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate;(R)-methyl 4-((3R,5R,6S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3,6-bis(tosyloxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
• CAS NO: 1184-20-9
• Molecular Weight: 714.985
• Mol File: 1184-20-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (4R)-Methyl 4-((3R,5R,6S,10R,13R,17R)-10,13-diMethyl-3,6-bis(tosyloxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-Methyl 4-((3R,5R,6S,10R,13R,17R)-10,13-diMethyl-3,6-bis(tosyloxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate(1184-20-9)
• EPA Substance Registry System: (4R)-Methyl 4-((3R,5R,6S,10R,13R,17R)-10,13-diMethyl-3,6-bis(tosyloxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate(1184-20-9)

Safety Data

• Hazardous Substances Data: 1184-20-9(Hazardous Substances Data)

Upstream product

• 83-49-8 Hyodeoxycholic Acid 
• 186581-53-3 diazomethane 
• 98-59-9 p-toluenesulfonyl chloride 
• 2868-48-6 methyl hyodeoxycholate 

Downstream Products

• 5255-17-4 3β-hydroxy-5-cholenoic acid 
• 20231-57-6 methyl 5-cholenoate 
• 31823-53-7 methyl 3β-acetoxychol-5-en-24-oate 
• 3633-72-5 Methyl-3β-acetoxychol-5-enoat 
• 84061-62-1 methyl 3β-tosyloxy-5α-cholan-24-oate 
• 1249-75-8 methyl 3β-hydroxy-5α-cholan-24-oate 
• 114011-35-7 3β-(t-butyldimethylsilyloxy)-5-cholenic acid methyl ester 
• 84529-86-2 (20R)-3β-(tert-butyldimethylsilyloxy)-24-hydroxy-25,26,27-trisnorcholest-5-ene 
• 1172-10-7 methyl cholan-3,5-dien-24-oate 
• 1452-33-1 methyl 3-oxo-4-cholenolate 
• 66414-44-6 3β-(tetrahydro-2H-pyran-2-yloxy)chol-5-en-24-al 
• 66414-43-5 3β-(tetrahydro-2H-pyran-2-yloxy)chol-5-en-24-ol 
• 51231-31-3 cholesta-5,24-diene-3β-ol 3-tetrahydropyran-2-yl ether 
• 2140-46-7 25-hydroxychlolesterol 

Relevant articles and documents

Novel 3,4-seco bile acid diamides as selective anticancer proliferation and migration agents

A series of new seco-A ring bile acid diamides were synthesized, and their antiproliferative activities against PC3M (prostate), HT29 (colon) and ES-2 (ovarian) cancer cell lines were investigated using SRB assays. Most synthesized compounds presented improved antiproliferative activities compared to the parent bile acids (IC50> 80 μM), especially the piperazine conjugated compound 27 with IC50values of 1.07, 4.58 and 3.86 μM against PC3M, HT29 and ES-2 cancer cell lines, respectively. In addition, all the tested compounds showed less cytotoxic activity on a noncancerous cell line (HAF), and the most active compound 27 exhibited the highest selectivity (Selectivity Index, SIPC3M= 26.3). Furthermore, 27 could also enhance G1 arrest in PC3M cell, revealed by cell cycle analysis, and increase anti-migration activity on PC3M cells, confirmed by transwell migration assay.

Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3β,7β-dihydroxy-5-cholen-24-oic acid, and related compounds: Unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1

The chemical synthesis of 3β,7β-dihydroxy-5-cholen-24-oic acid, triply conjugated by sulfuric acid at C-3, by N-acetylglucosamine (GlcNAc) at C-7, and by glycine or taurine at C-24, is described. These are unusual, major metabolites of bile acid found to

OXYSTEROLS AND METHODS OF USE THEREOF

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.