51231-31-3 Usage
Description
2-[(3β)-Cholesta-5,24-dien-3-yloxy]tetrahydro-2H-pyran is a chemical compound that serves as a protected intermediate in the synthesis of Desmosterol (D296860), which is a metabolite of Cholesterol (C432501). 2-[(3β)-Cholesta-5,24-dien-3-yloxy]tetrahydro-2H-pyran plays a crucial role in the chemical processes involved in the production of essential biological substances.
Uses
Used in Pharmaceutical Industry:
2-[(3β)-Cholesta-5,24-dien-3-yloxy]tetrahydro-2H-pyran is used as a protected intermediate for the synthesis of Desmosterol (D296860), a metabolite of Cholesterol (C432501). Its application is significant in the development of pharmaceuticals targeting cholesterol-related conditions and metabolic disorders.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-[(3β)-Cholesta-5,24-dien-3-yloxy]tetrahydro-2H-pyran is utilized as a key component in the production of various biologically active compounds. Its role in the synthesis process is essential for creating molecules with potential therapeutic applications.
Used in Research and Development:
2-[(3β)-Cholesta-5,24-dien-3-yloxy]tetrahydro-2H-pyran is also employed in research and development for studying the metabolic pathways of cholesterol and its related compounds. 2-[(3β)-Cholesta-5,24-dien-3-yloxy]tetrahydro-2H-pyran aids scientists in understanding the complex interactions and mechanisms involved in cholesterol metabolism, which can lead to the discovery of new therapeutic approaches for related health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 51231-31-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,2,3 and 1 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 51231-31:
(7*5)+(6*1)+(5*2)+(4*3)+(3*1)+(2*3)+(1*1)=73
73 % 10 = 3
So 51231-31-3 is a valid CAS Registry Number.
51231-31-3Relevant articles and documents
A concise synthesis of 25-Hydroxycholesterol from hyodesoxycholic Acid
Jin, Can,Wang, Yulei,Sun, Bin,Su, Weike
, p. 96 - 99 (2018/03/21)
A simple, efficient and economical method has been developed for the synthesis of 25-hydroxycholesterol in seven steps from hyodesoxycholic acid with an overall yield of 39%. The preparation of the 3β-tetrahydropyranyloxychol-5-en-24-al from 3β-tetrahydropyranyloxychol-5-en-24-oic acid methyl ester with di-isobutylaluminium hydride was achieved instead of using the conventional two-step reaction, thus avoiding the use of the toxic oxidant CrO3. The terminal product was obtained by hydroxybromination of desmosterol with N-bromosuccinimide/H2O, followed by reduction and deprotection of the halohydrins with LiAlH4. This simplified route gave an increased overall yield and used economical and environmentally benign reagents.
Synthesis of Cholesterol and Derivatives substituted in the Side chain
Kirk, David N.,Varley, Michael J.,Makin, Hugh L.J.,Trafford, David J.H.
, p. 2563 - 2567 (2007/10/02)
The carbanion derived from 24-phenylsulphonylchol-5-en-3β-ol 3-tetrahydropyranyl ether (6) reacted with acetone to give the 24-phenylsulphonyl-25-hydroxycholesterol derivative (7a), which was reduced by sodium amalgam to a separable mixture of the labelled 25-hydroxycholesterol and cholest-5,24-dien-3β-ol (desmosterol) derivatives. Cholesterol has been obtained via a selective reduction of the Δ24-unsaturation in desmosteryl benzoate with di-imide, or more efficiently by reducing 25-hydroxycholesteryl 3,25-diacetate w ith litium in ethylamine, without significant loss of label.The labelled 24,25-dihydroxycholesterols were also prepared from desmosteryl benzoate.
