118743-76-3

Basic information

• Product Name: 3(S)-(4-Benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidin-5-ol
• CAS NO: 118743-76-3
• Molecular Weight: 384.475
• Mol File: 118743-76-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3(S)-(4-Benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidin-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3(S)-(4-Benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidin-5-ol(118743-76-3)
• EPA Substance Registry System: 3(S)-(4-Benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidin-5-ol(118743-76-3)

Safety Data

• Hazardous Substances Data: 118743-76-3(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 118743-82-1 N-<4-(Benzyloxycarbonylamino)butylidene>-(R)-(-)-α-methylbenzylamine N-oxide 
• 69037-98-5 4-[(benzyloxycarbonyl)amino]butyric aldehyde 
• 17996-13-3 benzyl 4-hydroxybutylcarbamate 
• 118743-83-2 5-Acetoxy-3(S)-(4-benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidine 
• 118743-83-2 5-Acetoxy-3(R)-(4-benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidine 

Downstream Products

• 504-21-2 (3S)-β-lysine 
• 118743-79-6 (3S)-(4-Benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidin-5-one 
• 118743-78-5 (3R)-(4-Benzyloxycarbonylaminobutyl)-N-<(R)-(-)-α-methylbenzyl>isoxazolidin-5-one 

Relevant articles and documents

Asymmetric Syntheses of the Naturally Ocurring β-Amino Acids, β-Lysine, β-Leucine and β-Phenyl-β-alanine via Nitrone Cycloaddition

A general asymmetric synthesis of β-amino acids is based on the dipolar cycloaddition of nitrones 7 (R* chiral) with vinyl acetate 8a, ketene acetals 8b or α-chloroacrylonitrile 8c.The cycloadducts 9 are converted either directly (9b) or via the isoxazolidones 10 (9a, 9c) into the free β-amino acids 11.Diastereoselectivity at C-3 in the adducts 9 ranges between 2:1 and 11:1.The natural β-amino acids, β-lysine, β-leucine and β-phenyl-β-alanine, have been prepared in this way.