118799-81-8Relevant articles and documents
Comparative analysis of stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors with neuroprotective and anti-inflammatory activities
Nagumo, Mina,Ninomiya, Masayuki,Oshima, Natsuko,Itoh, Tomohiro,Tanaka, Kaori,Nishina, Atsuyoshi,Koketsu, Mamoru
supporting information, p. 2475 - 2479 (2019/07/30)
Stilbenes and benzofuran neolignans are important groups of plant phenolics therefore they play a significant role in plants and human health. The objective of this study was to investigate the structure-activity relationships of naturally occurring stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors. A series of these compounds were prepared and assessed for their inhibition on acetylcholinesterase activity. δ-Viniferin, pterostilbene trans-dehydrodimer, pallidol, grossamide, and boehmenan exerted acetylcholinesterase inhibitory potential. The several oligomeric compounds protected against cell damage resulting from t-BHP exposure and inhibited lipopolysaccharide/interferon-gamma (LPS/IFNγ)-induced NO production in vitro. Our findings highlight the great potential of pterostilbene trans-dehydrodimer, pallidol, and boehmenan as multifunctional nutraceuticals for management of neurodegenerative diseases.
Total Synthesis of Two Naturally Occurring Neolignans of Potential Biological Activity
Antus, Sandor,Gottsegen, Agnes,Kolonits, Pal,Wagner, Hildebert
, p. 593 - 594 (2007/10/02)
The first synthesis of the racemates of two naturally occurring neolignans, 1 and 2, was accomplished starting from methyl ferulate.