1190862-68-0 Usage
Description
Ethyl 5,6-dibromonicotinate is an organic compound that features a nicotinate core with two bromine atoms attached at the 5th and 6th positions. It is characterized by its potential reactivity and utility in the synthesis of various chemical entities.
Uses
Used in Pharmaceutical Industry:
Ethyl 5,6-dibromonicotinate is used as a reactant for the preparation of substituted pyridine compounds. These compounds are of interest as they can act as CRAC (Calcium Release-Activated Calcium) modulators, which are important in the development of drugs targeting various physiological and pathological processes.
Used in Chemical Synthesis:
In the field of chemical synthesis, ethyl 5,6-dibromonicotinate is utilized as a building block or intermediate in the creation of a wide range of organic molecules. Its reactivity and structural features make it a valuable component in the synthesis of complex organic compounds for research and industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1190862-68-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,0,8,6 and 2 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1190862-68:
(9*1)+(8*1)+(7*9)+(6*0)+(5*8)+(4*6)+(3*2)+(2*6)+(1*8)=170
170 % 10 = 0
So 1190862-68-0 is a valid CAS Registry Number.
1190862-68-0Relevant articles and documents
Application of 1,1-ADEQUATE, HMBC, and Density Functional Theory to Determine Regioselectivity in the Halogenation of Pyridine N-Oxides
Hwang, Tsang-Lin,Bartberger, Michael D.,Chen, Ying
, p. 1956 - 1959 (2016)
The 1,1-ADEQUATE spectrum clearly shows specific two-bond proton to carbon correlations to unequivocally distinguish the major and minor regioisomers of ortho-halogenated pyridines and to aid in assignment of the corresponding proton and carbon chemical shifts. M06-2X/6-31+G(d,p) free energies of the regioisomeric intermediates arising from deprotonation correctly predict the experimentally observed preference and thus can be used to tune the substituent pattern to yield a desired regiochemical outcome.
New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
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Page/Page column 55-56, (2009/10/21)
This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.