1191464-92-2

Basic information

• Product Name: (1R,2R,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-ol
• Synonyms: (1R,2R,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-ol
• CAS NO: 1191464-92-2
• Molecular Weight: 366.576
• Mol File: 1191464-92-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2R,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-ol(1191464-92-2)
• EPA Substance Registry System: (1R,2R,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-ol(1191464-92-2)

Safety Data

• Hazardous Substances Data: 1191464-92-2(Hazardous Substances Data)

Upstream product

• 135094-36-9 (1R,2S,4R,5S)-exo,exo-bicyclo[2.2.1]heptane-2,5-diol 
• 1334758-81-4 (1R,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-one 
• 1334758-61-0 (1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-ol 
• 1334758-60-9 ((1R,2S,4R,5S)-5-(benzyloxy)bicyclo[2.2.1]heptan-2-yloxy)(tert-butyl)diphenylsilane 
• 870708-23-9 (1R,2S,4R,5S)-5-(benzyloxy)bicyclo[2.2.1]heptan-2-ol 

Downstream Products

• 1191465-50-5 2-((1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-yl)isoindoline-1,3-dione 
• 1191465-55-0 1-((1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-yl)thiourea 
• 1334758-82-5 2-((1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-ylamino)-5-isopropylthiazol-4(5H)-one 
• 1334758-84-7 2-((1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one 

Relevant articles and documents

Synthesis and evaluation of the metabolites of AMG 221, a clinical candidate for the treatment of type 2 diabetes

All eight of the major active metabolites of (S)-2-((1S,2S,4R)-bicyclo[2.2. 1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221, compound 1), an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 that has entered the clinic for the treatm