1192344-37-8

Basic information

• Product Name: (RS)-5-(5-(2-amino-2-carboxyethyl)-2,3-dichlorophenyl)thiophene-2-carboxylic acid
• CAS NO: 1192344-37-8
• Molecular Weight: 360.218
• Mol File: 1192344-37-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (RS)-5-(5-(2-amino-2-carboxyethyl)-2,3-dichlorophenyl)thiophene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-5-(5-(2-amino-2-carboxyethyl)-2,3-dichlorophenyl)thiophene-2-carboxylic acid(1192344-37-8)
• EPA Substance Registry System: (RS)-5-(5-(2-amino-2-carboxyethyl)-2,3-dichlorophenyl)thiophene-2-carboxylic acid(1192344-37-8)

Safety Data

• Hazardous Substances Data: 1192344-37-8(Hazardous Substances Data)

Upstream product

• 615-65-6 2-chloro-4-methyl-benzenamine 
• 13711-29-0 2,3-dichloro-5-methylphenylamine 
• 13711-25-6 1,2-dichloro-5-methyl-3-nitrobenzene 
• 5465-33-8 2-chloro-4-methyl-6-nitroaniline 
• 1192344-08-3 diethyl 2-acetamido-2-(3,4-dichloro-5-(5-cyanothiophen-2-yl)benzyl)malonate 
• 1192343-91-1 diethyl 2-acetamido-2-(3,4-dichloro-5-iodobenzyl)malonate 
• 1192343-89-7 1,2-dichloro-3-iodo-5-methylbenzene 

Relevant articles and documents

3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands

On the basis of X-ray structures of ionotropic glutamate receptor constructs in complex with amino acid-based AMPA and kainate receptor antagonists, a series of rigid as well as flexible biaromatic alanine derivatives carrying selected hydrogen bond acceptors and donors have been synthesized in order to investigate the structural determinants for receptor selectivity between AMPA and the GluR5 subtype of kainate receptors. Compounds selective for either GluR5 or AMPA receptors were identified. One particular substituent position appeared to be of special importance for control of ligand selectivity. Using molecular modeling the observed structure-activity relationships at AMPA and GluR5 receptors were deduced.