5465-33-8 Usage
Description
2-Chloro-4-methyl-6-nitro-phenylamine is an organic compound with the molecular formula C7H7ClN2O2. It is characterized by the presence of a chlorine atom at the 2nd position, a methyl group at the 4th position, and a nitro group at the 6th position on a phenyl ring, with an amine group attached to the 1st position. 2-CHLORO-4-METHYL-6-NITRO-PHENYLAMINE is known for its reactivity and is commonly used as a reagent in the synthesis of various chemical compounds.
Uses
Used in Pharmaceutical Industry:
2-Chloro-4-methyl-6-nitro-phenylamine is used as a reagent for the preparation of phenylalanines, which are selective AMPA and kainate receptor ligands. These ligands play a crucial role in the development of drugs targeting neurological disorders and conditions related to the central nervous system. 2-CHLORO-4-METHYL-6-NITRO-PHENYLAMINE's ability to selectively bind to these receptors makes it a valuable tool in the pharmaceutical industry for the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 5465-33-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,6 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5465-33:
(6*5)+(5*4)+(4*6)+(3*5)+(2*3)+(1*3)=98
98 % 10 = 8
So 5465-33-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H7ClN2O2/c1-4-2-5(8)7(9)6(3-4)10(11)12/h2-3H,9H2,1H3
5465-33-8Relevant articles and documents
3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands
Szymanska, Ewa,Pickering, Darryl S.,Nielsen, Birgitte,Johansen, Tommy N.
experimental part, p. 6390 - 6401 (2011/03/17)
On the basis of X-ray structures of ionotropic glutamate receptor constructs in complex with amino acid-based AMPA and kainate receptor antagonists, a series of rigid as well as flexible biaromatic alanine derivatives carrying selected hydrogen bond acceptors and donors have been synthesized in order to investigate the structural determinants for receptor selectivity between AMPA and the GluR5 subtype of kainate receptors. Compounds selective for either GluR5 or AMPA receptors were identified. One particular substituent position appeared to be of special importance for control of ligand selectivity. Using molecular modeling the observed structure-activity relationships at AMPA and GluR5 receptors were deduced.
Pyridazinedione compounds useful in treating neurological disorders
-
, (2008/06/13)
The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]quinolines as active ingredient, and methods for the treatment of neurological disorders.
