1192833-21-8Relevant articles and documents
Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators
Iino, Tomoharu,Sasaki, Yasuhiro,Bamba, Makoto,Mitsuya, Morihiro,Ohno, Akio,Kamata, Kenji,Hosaka, Hideka,Maruki, Hiroko,Futamura, Mayumi,Yoshimoto, Riki,Ohyama, Sumika,Sasaki, Kaori,Chiba, Masato,Ohtake, Norikazu,Nagata, Yasufumi,Eiki, Jun-ichi,Nishimura, Teruyuki
scheme or table, p. 5531 - 5538 (2010/04/05)
We describe design, syntheses and structure-activity relationships of a novel class of 4,6-disubstituted quinazoline glucokinase activators. Prototype quinazoline leads (4 and 5) were designed based on the X-ray analyses of the previous 2-aminobenzamide lead classes. Modifications of the quinazoline leads led to the identification of a potent GK activator (21d).
