654-47-7

Basic information

• Product Name: 2-FLUOROPHENYLMETHYLSULFONE
• Synonyms: 1-Fluoro-2-(methylsulphonyl)Benzene;2-Fluorophenyl phenyl sulfone;2-Fluorophenyl methyl sulfone 97%;Benzene, 1-fluoro-2-(methylsulfonyl)-
• CAS NO: 654-47-7
• Molecular Formula: C₇H₇FO₂S
• Molecular Weight: 174.1926832
• Mol File: 654-47-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 51-53°C
• Boiling Point: 304.5 °C at 760 mmHg
• Flash Point: 110℃
• Appearance: /
• Density: 0.975
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-FLUOROPHENYLMETHYLSULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROPHENYLMETHYLSULFONE(654-47-7)
• EPA Substance Registry System: 2-FLUOROPHENYLMETHYLSULFONE(654-47-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 654-47-7(Hazardous Substances Data)

Usage

Description

2-FLUOROPHENYLMETHYLSULFONE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a fluorine atom attached to a phenyl ring and a sulfonyl group connected to a methyl group. This structure endows 2-FLUOROPHENYLMETHYLSULFONE with specific reactivity and properties that make it valuable in the field of medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
2-FLUOROPHENYLMETHYLSULFONE is used as a reagent for the synthesis of thiazolyl benzamides, which are novel allosteric glucokinase activators. These activators play a significant role in the regulation of glucose metabolism and have potential applications in the treatment of type 2 diabetes and other metabolic disorders. The unique structure of 2-FLUOROPHENYLMETHYLSULFONE allows for the efficient synthesis of these therapeutically relevant compounds, making it an essential component in the development of new drugs for metabolic diseases.

InChI:InChI=1/C7H7FO2S/c1-11(9,10)7-5-3-2-4-6(7)8/h2-5H,1H3

Upstream product

• 3112-85-4 methylphenylsulfonate 
• 462-06-6 fluorobenzene 
• 124-63-0 methanesulfonyl chloride 
• 7143-01-3 Methanesulfonic anhydride 

Downstream Products

• 916488-41-0 4-[2-(methylsulfonyl)phenyl]piperazine-1-carbaldehyde 
• 916488-42-1 1-[2-(methylsulfonyl)phenyl]piperazine dihydrochloride 
• 1147012-22-3 methyl 3-ethoxy-5-[2-(methylsulfonyl)phenoxy]-benzoate 
• 1147012-19-8 methyl 2-bromo-5-[2-(methylsulfonyl)phenoxy]benzoate 
• 1147012-23-4 methyl 3-isopropoxy-5-[2-(methylsulfonyl)phenoxy]-benzoate 
• 1188525-46-3 C₇H₆ClFO₄S₂ 
• 1204677-58-6 BOC-(S)-3-[(R)-(2-methanesulfonylphenoxy)phenylmethyl]pyrrolidine 
• 1192833-21-8 C₁₉H₁₆N₄O₃S₂ 
• 27489-33-4 2-hydroxyphenyl methyl sulfone 

Relevant articles and documents

Selective aromatic electrochemical fluorination of methyl phenyl sulfone

Electrochemical fluorination of methyl phenyl sulfone occurs exclusively at the aromatic ring to give isomeric methyl mono- and difluorophenyl sulfones and methyl 3,3,6,6-tetrafluoro-1,4-cyclohexadienyl sulfone.

Total Synergistic effect between triflic acid and bismuth(IIIr antimony(III) chlorides in catalysis of the Methanesulfonylation of Arenes

A total synergistic effect between bismuth(III) or antimony(III) chlorides and triflic acid has been observed in the Friedel-Crafts methanesulfonylation of arenes and has resulted in the development of the first efficient catalytic systems usable for the methanesulfonylation of both activated and deactivated arenes. A proposed mechanism to explain the observed effects is also discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.