1193116-74-3

Basic information

• Product Name: 5-broMo-2-(broMoMethyl)pyriMidine
• Synonyms: 5-broMo-2-(broMoMethyl)pyriMidine
• CAS NO: 1193116-74-3
• Molecular Formula: C5H4Br2N2
• Molecular Weight: 251.90666
• Mol File: 1193116-74-3.mol
• Article Data: 18

Chemical Properties

• Melting Point: 55-57 °C
• Boiling Point: 252.0±20.0 °C(Predicted)
• Appearance: /
• Density: 2.072±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.11±0.22(Predicted)
• CAS DataBase Reference: 5-broMo-2-(broMoMethyl)pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-2-(broMoMethyl)pyriMidine(1193116-74-3)
• EPA Substance Registry System: 5-broMo-2-(broMoMethyl)pyriMidine(1193116-74-3)

Safety Data

• Hazardous Substances Data: 1193116-74-3(Hazardous Substances Data)

Usage

General Description

5-bromo-2-(bromomethyl)pyrimidine is a chemical compound with the molecular formula C5H5Br2N2. It is a pyrimidine derivative that contains two bromine atoms and a bromomethyl group attached to the pyrimidine ring. 5-broMo-2-(broMoMethyl)pyriMidine is commonly used in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. It is often used as a building block in the synthesis of various biologically active compounds. The bromine atoms and the bromomethyl group on the pyrimidine ring make 5-bromo-2-(bromomethyl)pyrimidine a versatile and important compound in the field of organic chemistry.

Upstream product

• 7752-78-5 5-bromo-2-methylpyrimidine 
• 100707-39-9 5-bromo-2-methyl-pyrimidine-4-carboxylic acid 
• 89581-38-4 5-bromopyrimidine-2-carboxylic acid methyl ester 
• 22433-12-1 (5-bromopyrimidine-2-yl)methanol 
• 37131-87-6 5-bromo-2-pyrimidinecarboxylic acid 

Downstream Products

• 1235451-38-3 tert-butyl (5-bromopyrimidin-2-yl)methylcarbamate 
• 1240783-02-1 (5-bromopyrimidin-2-yl)methylamine 

Relevant articles and documents

Heterocyclic kinase inhibitor

The invention belongs to the technical field of medicines, and particularly relates to a heterocyclic DNA-PK kinase inhibitor compound shown as a general formula (I), a pharmaceutically acceptable salt and an isomer thereof, a pharmaceutical composition and preparation containing the compound, the pharmaceutically acceptable salt and the isomer thereof, a method for preparing the compound, the pharmaceutically acceptable salt and the isomer thereof, and application of the compound, the pharmaceutically acceptable salt and the isomer thereof.

BIARYLMETHYL HETEROCYCLES

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.