37131-87-6

Basic information

• Product Name: 5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID
• Synonyms: 5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID;5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID, 95+%;5-BroMo-2-pyriMidinecarboxylic acid;5-bromopyrimidin-2-carboxylic acid
• CAS NO: 37131-87-6
• Molecular Formula: C₅H₃BrN₂O₂
• Molecular Weight: 202.99
• Product Categories: Acids and Derivatives;Heterocycles;pharmacetical;Pyrimidine;Heterocycle-Pyrimidine series;carboxylic acid
• Mol File: 37131-87-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 193-198℃
• Boiling Point: 419.698 °C at 760 mmHg
• Flash Point: 207.626 °C
• Appearance: /Solid
• Density: 1.941 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.85±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID(37131-87-6)
• EPA Substance Registry System: 5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID(37131-87-6)

Safety Data

• Hazardous Substances Data: 37131-87-6(Hazardous Substances Data)

Usage

Description

5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID is an organic compound that serves as a crucial intermediate in various chemical syntheses. It is characterized by its unique molecular structure, which features a pyrimidine ring with a carboxyl group and a bromine atom at the 5th position. 5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID is known for its versatility in chemical reactions and its ability to be incorporated into a wide range of products.

Uses

Used in the Agrochemical Industry:
5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID is used as an important raw material and intermediate for the synthesis of various agrochemicals. Its unique chemical properties allow it to be incorporated into the development of new pesticides, herbicides, and other agricultural chemicals that can help improve crop yields and protect plants from pests and diseases.
Used in the Pharmaceutical Industry:
In the pharmaceutical sector, 5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID is utilized as a key intermediate in the synthesis of various drugs. Its molecular structure can be modified and combined with other compounds to create new pharmaceuticals with potential therapeutic applications, such as antibiotics, antivirals, and other therapeutic agents.
Used in the Dyestuff Industry:
5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID is also employed in the dyestuff industry as a vital intermediate for the production of various dyes and pigments. Its unique chemical properties enable the creation of a wide range of colors and shades, which can be used in various applications, such as textiles, plastics, and printing inks.

InChI:InChI=1/C5H3BrN2O2/c6-3-1-7-4(5(9)10)8-2-3/h1-2H,(H,9,10)

Upstream product

• 89166-80-3 5-bromo-2-tribromomethyl-pyrimidine 
• 68763-04-2 5-bromo-2-trans-styryl-pyrimidine 
• 5053-43-0 2-methylpyrimidine 
• 38275-57-9 5-bromopyrimidine-2-carbonitrile 
• 124-38-9 carbon dioxide 
• 183438-24-6 5-bromo-2-iodopyrimidine 

Downstream Products

• 4595-59-9 5-bromopyrimidine 
• 31519-62-7 pyrimidine-2-carboxylic acid 
• 89581-38-4 5-bromopyrimidine-2-carboxylic acid methyl ester 
• 85386-20-5 5-Phenylpyrimidine-2-carboxylic acid 
• 1013335-78-8 5-bromopyridine-2-carboxylic acid chloride 
• 1204130-30-2 5-(3,5-difluoro-4-((1-((1-methylcyclopropoxy)carbonyl)piperidin-4-yl)methoxy)phenyl)pyrimidine-2-carboxylic acid 
• 1262859-31-3 ((R)-5-{3-bromo-5-[(5-bromo-pyrimidine-2-carbonyl)-amino]-phenyl}-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester 
• 1262859-71-1 ((2R,5R)-5-{5-[(5-bromo-pyrimidine-2-carbonyl)-amino]-2-fluoro-phenyl}-2,5-di-methyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester 
• 915948-92-4 5-bromo-pyrimidine-2-carboxylic acid dimethylamide 
• 1352570-07-0 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide 
• 1419603-32-9 5-bromo-N-phenylpyrimidine-2-carboxamide 
• 1419603-34-1 5-bromo-N-phenyl-N-((2-(trimethylsilyl)ethoxy)methyl)pyrimidine-2-carboxamide 
• 1419603-19-2 5-bromo-N-(4-fluorophenyl)pyrimidine-2-carboxamide 
• 1419603-36-3 N-phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-((2-(trimethylsilyl)ethoxy)-methyl)pyrimidine-2-carboxamide 

Relevant articles and documents

Spirocyclic delta opioid receptor agonists for the treatment of pain: Discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4- yl) benzamide (ADL5747)

Selective, nonpeptidic δ opioid receptor agonists have been the subject of great interest as potential novel analgesic agents. The discoveries of BW373U86 (1) and SNC80 (2) contributed to the rapid expansion of research in this field. However, poor drug-like properties and low therapeutic indices have prevented clinical evaluation of these agents. Doses of 1 and 2 similar to those required for analgesic activity produce convulsions in rodents and nonhuman primates. Recently, we described a novel series of potent, selective, and orally bioavailable delta opioid receptor agonists. The lead derivative, ADL5859 (4), is currently in phase II proof-of-concept studies for the management of pain. Further structure activity relationship exploration has led to the discovery of ADL5747 (36), which is approximately 50-fold more potent than 4 in an animal model of inflammatory pain. On the basis of its favorable efficacy, safety, and pharmacokinetic profile, 36 was selected as a clinical candidate for the treatment of pain.

SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS

The present invention relates to a class of substituted 1,2,4-triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing, said, inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.).