119421-28-2Relevant articles and documents
Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors
Chen, Ting,Sorna, Venkataswamy,Choi, Susie,Call, Lee,Bearss, Jared,Carpenter, Kent,Warner, Steven L.,Sharma, Sunil,Bearss, David J.,Vankayalapati, Hariprasad
, p. 5473 - 5480 (2017)
In this work, we describe the use of the rule of 3 fragment-based strategies from biochemical screening data of 1100 in-house, small, low molecular weight fragments. The sequential combination of in silico fragment hopping and fragment linking based on S1
SUBSTITUTED BENZIMIDAZOLE CARBOXAMIDES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
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, (2021/04/01)
The invention provides substituted benzimidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.
NEW QUINOLINONE COMPOUNDS
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Page/Page column 73, (2019/01/17)
Provided are new quinolinone compounds, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds as FGFR inhibitors and their use in the treatment of diseases, e.g. cancer.
