3190-03-2

Basic information

• Product Name: SPIRO[3-AZAINDOLINE-2,1'-CYCLOHEXANE]
• Synonyms: SPIRO[3-AZAINDOLINE-2,1'-CYCLOHEXANE];AKOS 90316;SPIRO(CYCLOHEXANE-1,2'-BENZIMIDAZOLINE)
• CAS NO: 3190-03-2
• Molecular Formula: C₁₂H₁₆N₂
• Molecular Weight: 188.27
• Mol File: 3190-03-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SPIRO[3-AZAINDOLINE-2,1'-CYCLOHEXANE](CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[3-AZAINDOLINE-2,1'-CYCLOHEXANE](3190-03-2)
• EPA Substance Registry System: SPIRO[3-AZAINDOLINE-2,1'-CYCLOHEXANE](3190-03-2)

Safety Data

• Hazardous Substances Data: 3190-03-2(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 95-54-5 1,2-diamino-benzene 
• 27429-80-7 spiro[2H-benzimidazole-2,1'-cyclohexane] 

Downstream Products

• 100381-49-5 1-(cyclohex-1-enyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 100615-14-3 1-cyclohexyl-1,3-dihydro-2H-benzimidazol-2-one 
• 141421-22-9 5-phenylthio-2H-benzimidazole-2-spirocyclohexane 
• 141446-99-3 1,3-dihydro-6-phenylsulfonyl-5-(pyridin-2-ylthio)-2H-benzimidazole-2-spirocyclohexane 
• 155198-10-0 2-amino-4-(piperidin-1'-yl)aniline 
• 94526-22-4 5-phenylsulphonyl-4-piperidino-2H-benzimidazole-2-spirocyclohexane 
• 94526-23-5 4-morpholino-5-phenylsulphonyl-2H-benzimidazole-2-spirocyclohexane 
• 119421-28-2 4-morpholinobenzene-1,2-diamine 
• 94526-12-2 Cyclohexyl-spiro[benzoimidazole-2,1'-cyclohex]-5-yl-amine 
• 94526-13-3 Phenyl-spiro[benzoimidazole-2,1'-cyclohex]-5-yl-amine 
• 94526-54-2 5-(Toluene-4-sulfonyl)-1,3-dihydro-spiro[benzoimidazole-2,1'-cyclohexane] 
• 94526-53-1 5-(4-Chloro-benzenesulfonyl)-1,3-dihydro-spiro[benzoimidazole-2,1'-cyclohexane] 
• 94526-27-9 5-Benzenesulfonyl-spiro[benzoimidazole-2,1'-cyclohex]-4-ylamine 
• 94526-14-4 5,6-dianilinoisobenzoimidazole-2-spirocyclohexane 

Relevant articles and documents

Alumina supported 12-tungstophosphoric acid as an efficient and reusable catalyst for synthesis of 1,5-benzodiazepines

Alumina supported 12-tungstophosphoric acid catalyzes efficiently the reaction of o-phenylenediamine with ketones under solvent-free condition to afford the corresponding 1,5-benzodiazepines in good to excellent yields. The catalyst can be recovered and r

Reactions of fluoroalkyl-containing lithium 1,3-diketonates with diaminoarenes and 2-aminobenzenethiol

1,5-Benzo[b]- and 1,5-naphtho[2,3-b]diazepines were synthesized by the reaction of lithium 1,3-diketonates with 1,2-diaminobenzene and 2,3-diaminonaphthalene in an MeOH-AcOH-HCl mixture at 0°C. The reactions of fluoroalkyl-containing lithium 1,3-diketonates with 1,2-diaminobenzene and 1,2-diamino-4,5-difluorobenzene under reflux in acetic acid afford 2-fluoroalkyl-containing benzimidazoles as the major products, whereas the reaction with 2-aminothiophenol gives 2-phenylbenzothiazole. The reactions of lithium diketonate containing the cyclohexane and cyclopentane moieties with 1,2-diaminoarenes and 2-aminobenzenethiol are accompanied by the opening of the carbocycle to form 2-(6-oxo-7,7,7-trifluoroheptyl)benzimidazole and 2-(5-oxo-6,6,6-trifluorohexyl)benzothiazole hydrates, respectively.