119439-55-3

Basic information

• Product Name: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester
• Synonyms: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester
• CAS NO: 119439-55-3
• Molecular Weight: 436.505
• Mol File: 119439-55-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester(119439-55-3)
• EPA Substance Registry System: (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-succinic acid 4-tert-butyl ester(119439-55-3)

Safety Data

• Hazardous Substances Data: 119439-55-3(Hazardous Substances Data)

Upstream product

• 3391-99-9 N-Z-L-isoleucine N-hydroxysuccinimide ester 
• 3057-74-7 L-Asp(t-Bu) 
• 2130-99-6 α-carbobenzoxy-L-isoleucine p-nitrophenyl ester 

Downstream Products

• 119439-57-5 C₄₉H₇₄N₁₄O₁₅ 
• 119439-56-4 C₂₈H₄₃N₇O₁₀ 
• 119439-58-6 C₅₈H₉₇N₁₇O₁₆S 

Relevant articles and documents

Optimization of subsite binding to the β5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: Syntheses and cellular properties of potent, selective proteasome inhibitors

Beginning with the peptide sequence Cbz-Ile-Glu(OtBu)-Ala-Leu found in PSI (3), a series of vinyl sulfones (VS) were synthesized for evaluation as inhibitors of the chymotrypsin-like activity of the 20S proteasome. Variations at the key P3 position confir