1195785-00-2

Basic information

• Product Name: C₁₈H₁₃ClN₄
• Synonyms: C₁₈H₁₃ClN₄
• CAS NO: 1195785-00-2
• Molecular Weight: 320.781
• Mol File: 1195785-00-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₃ClN₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₃ClN₄(1195785-00-2)
• EPA Substance Registry System: C₁₈H₁₃ClN₄(1195785-00-2)

Safety Data

• Hazardous Substances Data: 1195785-00-2(Hazardous Substances Data)

Upstream product

• 17422-33-2 6-chloroindole 
• 703-82-2 6-chloro-1H-indole-3-carbaldehyde 
• 827-41-8 3-phenylpyrazol-5-amine 

Relevant articles and documents

Discovery of a highly selective FLT3 kinase inhibitor from phenotypic cell viability profiling

We discovered a novel molecular framework 4 containing a heterobiaryl pyrazolopyridine moiety as a selective FLT3 kinase inhibitor from phenotype-based viability profiling. Compound 4g showed outstanding selectivity in cellular cytotoxicity against MV-4-11 leukemic cells via the induction of apoptosis. The hypothesis-driven deconvolution elucidated that compound 4g selectively blocked the phosphorylation of FLT3 and its downstream effectors, such as ERK and STAT5, only in MV-4-11 cells. The inhibitory effect of 4g on in vitro enzyme function and FLT3 phosphorylation in cells proved that FLT3 kinase is a direct molecular target of 4g. Finally, the kinase activity profiling of 4g verified its excellent selectivity toward FLT3 over 40 representative kinases, including the receptor tyrosine kinase (RTK) family. The Royal Society of Chemistry 2013.