703-82-2Relevant articles and documents
Synthesis and optimization of new 3,6-disubstitutedindole derivatives and their evaluation as anticancer agents targeting the MDM2/MDMx complex
Rezk, Mohamed Salah,Abdel-Halim, Mohammad,Keeton, Adam,Franklin, Derek,Bauer, Matthias,Boeckler, Frank Michael,Engel, Matthias,Hartmann, Rolf Wolfgang,Zhang, Yanping,Piazza, Gary Anthony,Abadi, Ashraf Hassan
, p. 34 - 41 (2016)
Twelve derivatives of the general formula 3-substituted-6-chloroindoles were synthesized and tested for their growth inhibitory effects versus p53+/+ colorectal cancer HCT116 and its p53 knockout isogenic cells; colorectal cancer cell p53-
Structural Rigidification of N-Aryl-pyrroles into Indoles Active against Intracellular and Drug-Resistant Mycobacteria
Semenya, Dorothy,Touitou, Meir,Ribeiro, Camila Maringolo,Pavan, Fernando Rogerio,Pisano, Luca,Singh, Vinayak,Chibale, Kelly,Bano, Georg,Toscani, Anita,Manetti, Fabrizio,Gianibbi, Beatrice,Castagnolo, Daniele
supporting information, p. 63 - 69 (2021/12/17)
A series of indolyl-3-methyleneamines incorporating lipophilic side chains were designed through a structural rigidification approach and synthesized for investigation as new chemical entities against Mycobacterium tuberculosis (Mtb). The screening led to the identification of a 6-chloroindole analogue 7j bearing an N-octyl chain and a cycloheptyl moiety, which displayed potent in vitro activity against laboratory and clinical Mtb strains, including a pre-extensively drug-resistant (pre-XDR) isolate. 7j also demonstrated a marked ability to restrict the intracellular growth of Mtb in murine macrophages. Further assays geared toward mechanism of action elucidation have thus far ruled out the involvement of various known promiscuous targets, thereby suggesting that the new indole 7j may inhibit Mtb via a unique mechanism.
Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus
Hu, Yuanyuan,Hu, Chunfang,Pan, Guangxing,Yu, Congwei,Ansari, Mohammad Fawad,Yadav Bheemanaboina, Rammohan R.,Cheng, Yu,Zhou, Chenghe,Zhang, Jiaheng
, (2021/06/16)
The increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics has led to a growing effort to design and synthesize novel structural candidates of chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids with