119725-40-5

Basic information

• Product Name: beta-Hydroxy-beta-methyl-alpha-phenyl-(1,1'-biphenyl)-4-propanoic acid, (R',R')-DL-
• Synonyms: beta-Hydroxy-beta-methyl-alpha-phenyl-(1,1'-biphenyl)-4-propanoic acid, (R',R')-DL-
• CAS NO: 119725-40-5
• Molecular Formula: C22H20O3
• Molecular Weight: 332.3924
• Mol File: 119725-40-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 493.8°Cat760mmHg
• Flash Point: 266.6°C
• Appearance: /
• Density: 1.208g/cm³
• PKA: 3.80±0.12(Predicted)
• CAS DataBase Reference: beta-Hydroxy-beta-methyl-alpha-phenyl-(1,1'-biphenyl)-4-propanoic acid, (R',R')-DL-(CAS DataBase Reference)
• NIST Chemistry Reference: beta-Hydroxy-beta-methyl-alpha-phenyl-(1,1'-biphenyl)-4-propanoic acid, (R',R')-DL-(119725-40-5)
• EPA Substance Registry System: beta-Hydroxy-beta-methyl-alpha-phenyl-(1,1'-biphenyl)-4-propanoic acid, (R',R')-DL-(119725-40-5)

Safety Data

• Hazardous Substances Data: 119725-40-5(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 92-91-1 biphenyl-4-acetaldehyde 
• 119725-40-5 3-Biphenyl-4-yl-3-hydroxy-2-phenyl-butyric acid 

Downstream Products

• 119725-41-6 3-Biphenyl-4-yl-3-hydroxy-2-phenyl-butyric acid methyl ester 
• 119725-41-6 3-Biphenyl-4-yl-3-hydroxy-2-phenyl-butyric acid methyl ester 
• 119725-40-5 3-Biphenyl-4-yl-3-hydroxy-2-phenyl-butyric acid 
• 119725-40-5 3-Biphenyl-4-yl-3-hydroxy-2-phenyl-butyric acid 

Relevant articles and documents

Nonsteroidal anti-inflammatory agents. 19. Synthesis and activity of stereomeric phenylacetic homologues

The authors synthesized the title compounds as analogues of previously prepared potential antiphlogistic agents. Starting from appropriate carbonyl compound and alpha-metallated phenylacetic acid the diastereomeric racemate pairs were obtained; they were separated, attributed to erythro/threo-configuration by NMR and finally resolved. The potassium salts of the enantiomers were tested for analgesic and antiinflammatory activity, as well as for acute toxicity. Their action in the carrageenan test has been found to be stereoselective, but relatively poor or of briefly lastening.