1198-15-8

Basic information

• Product Name: 1-methyl-1,2,3,4-tetrahydroquinolin-4-one
• Synonyms: 1-methyl-1,2,3,4-tetrahydroquinolin-4-one
• CAS NO: 1198-15-8
• Molecular Weight: 161.203
• Mol File: 1198-15-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 130 °C(Press: 0.1 Torr)
• Density: 1.120±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-methyl-1,2,3,4-tetrahydroquinolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-1,2,3,4-tetrahydroquinolin-4-one(1198-15-8)
• EPA Substance Registry System: 1-methyl-1,2,3,4-tetrahydroquinolin-4-one(1198-15-8)

Safety Data

• Hazardous Substances Data: 1198-15-8(Hazardous Substances Data)

Usage

Classification

Organic compound
Belongs to the quinolone family.

Usage

Widely used in pharmaceutical and medicinal chemistry.

Biological activities

Antitumor properties.
Anti-inflammatory properties.
Anticonvulsant properties.

Enzyme inhibition

Inhibits lipoxygenase.
Involved in the production of leukotrienes, which are inflammatory mediators.

Chemical structure

Versatile building block.
Used for the synthesis of various drugs and bioactive compounds.

Importance

Important intermediate in the production of pharmaceuticals.
Potential applications in drug discovery and development.

Upstream product

• 1407968-49-3 4-[N-(2-iodophenyl)-N-methylamino]butanal 
• 1407968-57-3 4-[N-(2-iodophenyl)-N-methylamino]butanol 
• 57056-89-0 N-(but-3-en-1-yl)-2-iodo-N-methylaniline 
• 615-43-0 2-iodophenylamine 
• 118670-86-3 N-(but-3-en-1-yl)-2-iodoaniline 
• 1088708-50-2 3-[N-(2-iodophenyl)-N-methylamino]-N-methoxy-N-methylpropanamide 
• 1088708-44-4 3-[N-(2-iodophenyl)-N-methylamino]-N,N-dimethylpropanamide 
• 4295-36-7 2,3-dihydroquinolin-4(1H)-one 
• 74-88-4 methyl iodide 
• 100-61-8 N-methylaniline 
• 7446-70-0 aluminium trichloride 
• 94-34-8 N-(2-cyanoethyl)-N-methylaniline 
• 2680-03-7 N,N-Dimethylacrylamide 
• 3334-56-3 N-methyl-N-(2-[hydroxycarbonyl]ethyl)aniline 

Downstream Products

• 99057-84-8 6-bromo-1-methyl-2,3-dihydroquinolin-4-one 
• 56857-96-6 1-methyl-3-phenylquinolin-4(1H)-one 
• 719-54-0 10-methyl-9, 10-dihydro-9-acridinone 
• 851390-46-0 1-methyl-1,2,3,4-tetrahydro-4-quinolinamine 
• 107520-34-3 6,8-dibromo-3-(4-dimethylamino-anilino)-1-methyl-1H-quinolin-4-one 
• 107621-79-4 6-bromo-3-(4-dimethylamino-anilino)-1-methyl-1H-quinolin-4-one 
• 108623-43-4 6-bromo-3-(4-dimethylamino-benzylidene)-1-methyl-2,3-dihydro-1H-quinolin-4-one 
• 83-54-5 1-methyl-4-quinolone 
• 3835-09-4 1-methyl-2,3-dihydro-1H-quinolin-4-one-(2,4-dinitro-phenylhydrazone) 
• 101782-93-8 3-(4-dimethylamino-anilino)-1-methyl-1H-quinolin-4-one 
• 109094-25-9 3-(4-dimethylamino-benzylidene)-1-methyl-2,3-dihydro-1H-quinolin-4-one 
• 121113-03-9 1,2,3,4-tetrahydro-1-methyl-4-oxoquinoline phenylhydrazone 

Relevant articles and documents

Control over the chemoselectivity of Pd-catalyzed cyclization reactions of (2-iodoanilino)carbonyl compounds

The factors that control the chemoselectivity of palladium-catalyzed cyclization reactions of (2-iodoanilino)carbonyl compounds have been explored by an extensive experimental computational (DFT) study. It was found that the selectivity of the process, th

PIPERIDINE DERIVATIVES AS HDAC1/2 INHIBITORS

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDACl and/or HDAC2 activity.

Intramolecular Pd(0)-catalyzed reactions of (2-iodoanilino)-aldehydes: A joint experimental-computational study

An extensive joint experimental-computational density functional theory (DFT) study has been carried out to gain insight into the factors that control the chemoselectivity (i.e., acylation vs α-arylation reaction) of palladium-catalyzed cyclizations of (2-iodoanilino)-aldehydes. To this end, the nature of the tethers joining the aniline nitrogen and the aldehyde moiety, different palladium precatalysts and reaction conditions (base and temperature), as well as different additives (mono- and bidendate ligands) has been explored. The adequate selection of these variables allows for the control of the selectivity of the process. Thus, (2-iodoanilino)-aldehydes generally lead to the formation of nucleophilic addition derived products when Cs 2CO3/Et3N is used as base. In contrast, the use of stronger bases like KtOBu (in the presence of PhOH) mainly forms α-arylation reaction products. The different reaction pathways leading to the experimentally observed reaction products have been studied by means of computational tools.