2680-03-7Relevant articles and documents
Batyeva et al.
, (1976)
Amide bond formation in aqueous solution: Direct coupling of metal carboxylate salts with ammonium salts at room temperature
Nielsen, John,Tung, Truong Thanh
supporting information, p. 10073 - 10080 (2021/12/10)
Herein, we report a green, expeditious, and practically simple protocol for direct coupling of carboxylate salts and ammonium salts under ACN/H2O conditions at room temperature without the addition of tertiary amine bases. The water-soluble coupling reagent EDC·HCl is a key component in the reaction. The reaction runs smoothly with unsubstituted/substituted ammonium salts and provides a clean product without column chromatography. Our reaction tolerates both carboxylate (which are unstable in other forms) and amine salts (which are unstable/volatile when present in free form). We believe that the reported method could be used as an alternative and suitable method at the laboratory and industrial scales. This journal is
PRODUCTION METHOD OF N,N-DISUBSTITUTED α,β-UNSATURATED CARBOXYLIC ACID AMIDE AND CATALYST FOR PRODUCTION OF N,N-DISUBSTITUTED α,β-UNSATURATED CARBOXYLIC ACID AMIDE
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Paragraph 0070-0101, (2020/03/31)
To provide a production method capable of producing N,N-disubstituted α,β-unsaturated carboxylic acid amide by a gas phase reaction.SOLUTION: The production method is a method for producing N,N-disubstituted α,β-unsaturated carboxylic acid amide by subjecting N,N-disubstituted carboxylic acid amide and aldehydes to a gas phase reaction in the presence of a catalyst. The catalyst includes an oxide of a first metal element being a metal element of Group 2 of the Periodic Table and an oxide of a second metal element being at least one kind of metal element selected from the group consisting of Mn, Cr, Co, Ni and Zn and has a mole ratio of the second metal element to the total mole number of the first metal element and the second metal element of 0.01 to 0.20.SELECTED DRAWING: None
N, N - disubstituted α, β - unsaturated carboxylic acid amide of (by machine translation)
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Paragraph 0059; 0060, (2019/06/07)
[Problem] to compounds derived from compounds containing chlorine atoms contained in the byproducts of the no possibility, stable compound to N, N - disubstituted α, β - unsaturated carboxylic acid amide manufacturing method. [Solution] N, N - di-substituted carboxylic acid amide phenols with formaldehyde, in the presence of a catalyst containing no chlorine atoms, in a nonaqueous liquid phase reaction, N, N - disubstituted α, β - unsaturated carboxylic acid amide having a process, wherein the formaldehyde, paraformaldehyde, trioxane is one selected from formaldehyde and anhydrous 1, 3, 5 - 1, and the catalyst, an acidic catalyst or a basic catalyst N, α N - disubstituted, with production of β - unsaturated carboxylic acid amide. [Drawing] no (by machine translation)