1608-26-0 Usage
Description
Hexamethylphosphorous triamide, also known as HMPA, is a colorless liquid with a wide range of industrial applications. It is a classified carcinogen, which highlights the need for caution in its handling and use.
Uses
Used in Building Materials Industry:
Hexamethylphosphorous triamide is used as a flame retardant for building materials to enhance their fire resistance and safety.
Used in Synthetic Chemistry:
Hexamethylphosphorous triamide is used as a phosphorylating agent in synthetic chemistry, facilitating various chemical reactions and syntheses.
Used in Suzuki Reaction:
In the field of organic chemistry, Hexamethylphosphorous triamide is used in the Suzuki reaction, a widely employed method for the formation of carbon-carbon bonds.
Used in Organic Synthesis:
Hexamethylphosphorous triamide is used in combination with CCl4 for the conversion of hydroxyl groups to the corresponding chlorides, hydroxyl group activation, and dehydrations, which are essential steps in the synthesis of various organic compounds.
Purification Methods
It may contain more than 1% of phosphoric triamide. The yellow oil is first distilled at atmospheric pressure, then under reduced pressure and stored under N2. It is air sensitive, TOXIC, and should not be inhaled. It is absorbed through the skin. [Mark Org Synth Coll Vol V 602 1973, Beilstein 4 IV 274.]
Check Digit Verification of cas no
The CAS Registry Mumber 1608-26-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,0 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1608-26:
(6*1)+(5*6)+(4*0)+(3*8)+(2*2)+(1*6)=70
70 % 10 = 0
So 1608-26-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H18N3P/c1-7(2)10(8(3)4)9(5)6/h1-6H3
1608-26-0Relevant articles and documents
Phosphorylation of chitin with tris(dimethylamino)phosphine
Kudryavtsev,Matrosov,Nifant'ev
, p. 179 - 181 (2008)
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Novel Di-isopropylamino Derivatives of Trivalent Phosphorus
King, R. Bruce,Sadanani, Narayan D.,Sundaram, Ponnuswamy M.
, p. 477 - 478 (1983)
Reduction of (iPr2N)2PCl with LiAlH4 in diethyl ether gives (iPr2N)2PH; reaction of iPr2NPCl2 with Mg in boiling tetrahydrofuran gives either the cyclotetraphosphine (iPr2N)4P4 or the 1,2-dichlorobiphosphine iPr2NP(Cl)-P(Cl)NiPr2 depending upon the Mg:iPr2NPCl2 mole ratio.
Cyclization of C-phosphorylated (PIII) arylformamidines to 3H-1,3-benzazaphospholes
Marchenko, Anatolyi,Koidan, Heorgii,Hurieva, Anastasiya,Merkulov, Anatolyi,Pinchuk, Aleksandr,Yurchenko, Aleksandr,Rozhenko, Alexander B.,Jones, Peter G.,Th?nnessen, Holger,Kostyuk, Aleksandr
experimental part, p. 7748 - 7758 (2011/10/17)
A synthesis of 3H-1,3-benzazaphospholes starting from C-phosphorylated P(III) arylformamidines has been developed. Electron-donating substituents were found to enhance markedly the rate of the cyclization, with substituents at the meta position having the greatest effect. A plausible mechanism of the cyclization was proposed based on DFT calculations.
Dismutation of diamidoarylphosphites
Nifantyev, Edward E.,Rasadkina, Elena N.,Slitikov, Pavel V.,Vasyanina, Larisa K.
, p. 2465 - 2477 (2007/10/03)
Some examples of spontaneous dismutation of diamidoarylphosphites in different solvents were studied, and features of the process were revealed.