2083-91-2 Usage
Description
N,N-Dimethyltrimethylsilylamine, also known as N-(trimethylsilyl)dimethylamine, is a clear colorless to pale yellow liquid with versatile applications in various industries. It is a derivative of trimethylsilylamine, featuring a trimethylsilyl group attached to a dimethylamino group. N,N-Dimethyltrimethylsilylamine is known for its reactivity and stability, making it a valuable component in chemical synthesis and modification processes.
Uses
Used in Chemical Synthesis:
N,N-Dimethyltrimethylsilylamine is used as a reagent for the synthesis of phosphoramidite, a key component in the production of oligonucleotides and nucleic acid probes. Its ability to facilitate the formation of phosphoramidite linkages makes it an essential tool in the field of molecular biology and biotechnology.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N,N-Dimethyltrimethylsilylamine is employed as a reagent in the preparation of iminium salts and amides. These intermediates are crucial for the synthesis of various pharmaceutical compounds, including drugs and drug candidates.
Used in Polymer Industry:
N,N-Dimethyltrimethylsilylamine is used for the silylation of polymers, a process that involves the introduction of a trimethylsilyl group to a polymer chain. This modification can enhance the polymer's properties, such as its stability, reactivity, or solubility, making it suitable for various applications, including coatings, adhesives, and elastomers.
Used in Organic Chemistry:
N,N-Dimethyltrimethylsilylamine has been used in combination with other reagents, such as MeI, to achieve high yields in organic reactions. For example, a combination of N-(trimethylsilyl)dimethylamine and MeI was effective in producing p-methylbenzoic acid with an 85% yield based on 90% conversion from the corresponding Me ester.
Used in Silylated Derivatives Synthesis:
N,N-Dimethyltrimethylsilylamine has been utilized in the synthesis of mono-, di-, and tri-silylated derivatives of DETA (diethylenetriamine). These silylated derivatives exhibit unique properties and can be used in various applications, such as additives, catalysts, or intermediates in the chemical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 2083-91-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,8 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2083-91:
(6*2)+(5*0)+(4*8)+(3*3)+(2*9)+(1*1)=72
72 % 10 = 2
So 2083-91-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H21NSi2/c1-8(9(2,3)4)10(5,6)7/h1-7H3
2083-91-2Relevant articles and documents
Hewson,Schmutzler
, p. 179,181,184 (1978)
Latent Nucleophilic Carbenes
Hurieva, Anastasiya,Koidan, Georgyi,Kostyuk, Aleksandr,Kyrylchuk, Andrii A.,Marchenko, Anatoliy,Rozhenko, Alexander B.,Rusanov, Eduard B.,Shvydenko, Kostiantyn
, (2021/12/27)
Using DFT and ab initio calculations, we demonstrate that noncyclic formamidines can undergo thermal rearrangement into their isomeric aminocarbenes under rather mild conditions. We synthesized the silylformamidine, for which the lowest activation energy in this process was predicted. Experimental studies proved it to serve as a very reactive nucleophilic carbene. The reactions with acetylenes, benzenes, and trifluoromethane proceeded via insertion into sp, sp2, and spCH bonds. The carbene also reacted with the functional groups, such as CHO, COR, and CN at double or triple bonds, displaying high mobility of the trimethylsilyl group. The obtained silylformamidine can be considered as a latent nucleophilic carbene. It can be prepared in bulk quantities, stored, and used when the need arises. Calculation results predict similar behavior for some other silylated formamidines and related compounds.
Organic [...] compound
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Paragraph 0069; 0070; 0071; 0072; 0073; 0074; 0075-0078, (2018/05/26)
This method for producing an organic silyl amine compound (3) represented by general formula (3) is characterized in that ammonia is removed by reactive distillation when an organic disilazane compound (1) represented by general formula (1) is reacted with an alkyl amine represented by general formula (2). An organic silyl amine compound can be obtained by this production method with high productivity without producing a salt. (In the formulae, each of R1, R2 and R3 independently represents a linear or branched alkyl group having 1-7 carbon atoms, a cyclic alkyl group having 3-5 carbon atoms or a phenyl group; and each of R4 and R5 independently represents a hydrogen atom, a linear or branched alkyl group having 1-5 carbon atoms or a cyclic alkyl group having 3-5 carbon atoms, provided that R4 and R5 are not hydrogen atoms at the same time.)
An Alumino-Mannich Reaction of Organoaluminum Reagents, Silylated Amines, and Aldehydes
Tarasewicz, Anika,Ensan, Deeba,Batey, Robert A.
supporting information, p. 6071 - 6074 (2018/04/27)
A multi-component coupling using organoaluminum reagents, silylated amines, and aldehydes results in the formation of tertiary amines. Both alkenyl- and alkylaluminum reagents undergo reaction with iminium ion substrates for which the corresponding Petasis borono-Mannich reactions are unsuccessful.