33697-33-5

Basic information

• Product Name: <(Dimethylamino)phenylmethyl>phosphonic Bis(dimethylamide)
• Synonyms: <(Dimethylamino)phenylmethyl>phosphonic Bis(dimethylamide)
• CAS NO: 33697-33-5
• Molecular Weight: 269.327
• Mol File: 33697-33-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: <(Dimethylamino)phenylmethyl>phosphonic Bis(dimethylamide)(CAS DataBase Reference)
• NIST Chemistry Reference: <(Dimethylamino)phenylmethyl>phosphonic Bis(dimethylamide)(33697-33-5)
• EPA Substance Registry System: <(Dimethylamino)phenylmethyl>phosphonic Bis(dimethylamide)(33697-33-5)

Safety Data

• Hazardous Substances Data: 33697-33-5(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 124-40-3 dimethyl amine 
• 1608-26-0 Hexamethylphosphorous triamide 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 2083-91-2 N,N-Dimethyltrimethylsilylamine 
• 5843-26-5 tetramethylphosphorodiamidous acid 
• 13880-55-2 N,N,N',N'-tetramethyl-C-phenylmethanediamine 

Downstream Products

• 451-40-1 phenyl benzyl ketone 
• 56437-43-5 (E)-1.2-Diphenyl-1-N_.N-dimethylaminoethen 
• 27356-33-8 2-(2-methoxyphenyl)-1-phenylethan-1-one 
• 134542-39-5 [(E)-2-(2-Methoxy-phenyl)-1-phenyl-vinyl]-dimethyl-amine 
• 134542-40-8 ((E)-2-Benzo[1,3]dioxol-5-yl-1-phenyl-vinyl)-dimethyl-amine 
• 40804-81-7 2-(benzo[d][1,3]dioxol-5-yl)-1-phenylethan-1-one 

Relevant articles and documents

Preparation of 1-substituted-5-[(2-oxo-2-phenyl)ethyl]imidazoles

New high yield preparation methods were developed for the pharmaceutically interesting compounds, 1-benzyl-, 1-methyl-, and 1H-5-[(2- oxo-2-phenyl)ethyl]imidazoles 1a-c, respectively. The title compounds were synthesized by four different methods using various starting materials. Two of the methods involved transformation reactions of the key intermediates, 1- substituted-5-[(2-nitro-2-phenyl)ethenyl]imidazoles 2a-c and 1-substituted-5- [(2-nitro-2-phenyl)ethyl]imidazoles 3a-c, while the other two utilized the oxidation of 1-substituted-5-[(2-hydroxy-2-phenyl)ethyl]imidazoles 4a-c, with chromic oxide, and the umpolung reaction of benzaldehyde followed by a condensation reaction of the umpolung intermediate with imidazolecarboxaldehydes 6a-c.

The reaction of arylaldehydes with hexamethylphosphorous triamide and the use of the resulting products for the synthesis of enamines and deoxybenzoins

The reaction between the arylaldehydes 1a,b and hexamethylphosphorous triamide 2 leads to the [aryl(dimethylamino)methyl]phosphonic bis(dimethylamides) 3a,b. These can be easily deprotonated by butyllithium in 1,2-dimethoxyethane and condensed with arylaldehydes to afford enamines 4a-f or deoxybenzoins 5a-f in fair to good yield.