1198118-32-9

Basic information

• Product Name: (4R,5R)-methyl 4,5-dimethyl-5-phenyl-2-thioxooxazolidine-4-carboxylate
• Synonyms: (4R,5R)-methyl 4,5-dimethyl-5-phenyl-2-thioxooxazolidine-4-carboxylate
• CAS NO: 1198118-32-9
• Molecular Weight: 293.387
• Mol File: 1198118-32-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4R,5R)-methyl 4,5-dimethyl-5-phenyl-2-thioxooxazolidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-methyl 4,5-dimethyl-5-phenyl-2-thioxooxazolidine-4-carboxylate(1198118-32-9)
• EPA Substance Registry System: (4R,5R)-methyl 4,5-dimethyl-5-phenyl-2-thioxooxazolidine-4-carboxylate(1198118-32-9)

Safety Data

• Hazardous Substances Data: 1198118-32-9(Hazardous Substances Data)

Upstream product

• 2550-26-7 4-Phenyl-2-butanone 
• 26349-74-6 2-isothiocyanatopropionic acid methyl ester 

Relevant articles and documents

Construction of contiguous tetrasubstituted chiral carbon stereocenters via direct catalytic asymmetric aldol and mannich-type reactions

Catalytic asymmetric synthesis of unnatural amino acids with vicinal tetrasubstituted chiral carbon stereocenters is described. In the first part, direct catalytic asymmetric aldol reaction of simple non-activated ketone electrophiles with α-substituted α-isothiocyanato ester donors was realized. A Mg/Schiff base catalyst promoted the aldol reaction, and α-amino-β-hydroxy esters were obtained in up to 98% ee and 98:2 d.r. In the second part, the Mg/Schiff base catalyst and a Sr/Schiff base catalyst were utilized for stereodivergent direct asymmetric Mannich-type reaction of ketimines. The Mg/Schiff base catalyst gave syn-α,β-diamino esters, while the Sr/Schiff base catalyst produced anti-α,β-diamino esters in good to high enantioselectivity, up to 97% ee.