119841-71-3Relevant articles and documents
Environmentally benign syntheses of flavanones
Chen, Po-Yuan,Wang, Tzu-Pin,Chiang, Michael Y.,Huang, Keng-Shian,Tzeng, Cherng-Chyi,Chen, Yi-Long,Wang, Eng-Chi
experimental part, p. 4155 - 4160 (2011/06/26)
Mild and environmentally benign methods for the syntheses of flavanones are described. The reaction of o-hydroxyacetophenones (1) and benzaldehydes (2) in water in the presence of DABCO at room temperature gave 3-hydroxy-1-(2- hydroxylphenyl)-3-arylpropan-1-ones (3a-i) as intermediates. Followed by an intramolecular dehydration of the 3a-i with the modified Mitsunobu's reaction, the target flavanones (4a-i) were obtained. Moreover, the reaction of 1 and 2 at the same conditions but at reflux gave flavanones in one pot with good yields.
Synthesis and preliminary biological evaluation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones, a new class of calcium entry blockers
Manna, Fedele,Chimenti, Franco,Bolasco, Adriana,Bizzarri, Bruna,Botta, Maurizio,Tafi, Andrea,Filippelli, Amelia,Rossi, Settimio
, p. 1883 - 1885 (2007/10/03)
The preparation of 3-cyano-4,6-diaryl-pyridin-2(1H)-ones 4a-h, calcium entry blockers related to diltiazem, is described starting from 1,3-diaryl-2-propen-1-ones 5. On preliminary pharmacological tests all compounds are active and some of them show calcium antagonistic activity superior or comparable to diltiazem. (C) 2000 Elsevier Science Ltd. All rights reserved.
