577-85-5Relevant articles and documents
Transient Absorption Study of the Intramolecular Excited-State and Ground-State Proton Transfer in 3-Hydroxyflavone and 3-Hydroxychromone
Itoh, Michiya,Tanimoto, Yoshifumi,Tokumura, Kunihiro
, p. 3339 - 3340 (1983)
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Direct evidence of excited-state intramolecular proton transfer in 2'-hydroxychalcone and photooxygenation forming 3-hydroxyflavone
Chou,Matinez,Cooper
, p. 4943 - 4944 (1992)
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Proton Transfer in Matrix-Isolated 3-Hydroxyflavone and 3-Hydroxyflavone Complexes
Brucker, G. A.,Kelley, D. F.
, p. 2856 - 2861 (1987)
The proton-transfer dynamics of 3-hydroxyflavone (3HF) and 3HF-solvent complexes have been studied in 10 K argon matrices.Both static and picosecond fluorescence spectroscopies were used.The results indicate that proton transfer in bare molecules occurs quite rapidly (10 ps).The 3HF-solvent complexes are formed by codeposition of argon:solvent mixtures (typically 2000:1) with 3HF followed by matrix annealing.Solvents include water, methanol, ethanol, and diethyl ether.The results show that proton transfer is very fast (10 ps) in alkohol and water monosolvates and can be interpreted in terms of cyclically hydrogen-bonded structures.The results also show that the diethyl ether monosolvate undergoes proton transfer in about 40 ps.Solvation with two or more waters or alkohols was found to inhibit proton transfer.
COMPOSITION FOR IMPROVING RESPIRATORY HEALTH CONTINUOUSLY EXPOSED TO PARTICULATE MATTER ATMOSPHERE
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, (2021/12/17)
An aspect of the present disclosure relates to a composition for improving respiratory health exposed to particulate matter, which contains a green tea extract, a green tea polysaccharide and a green tea flavonol as active ingredients. The composition provided in an aspect of the present disclosure can improve respiratory health damaged by exposure to particulate matter by enhancing the effect of preventing adsorption of particulate matter to bronchial epithelial cells and activating the cilia of bronchial epithelial cells. The composition provided in an aspect of the present disclosure may decrease blood heavy metal level.
Exploring 3-hydroxyflavone scaffolds as mushroom tyrosinase inhibitors: synthesis, X-ray crystallography, antimicrobial, fluorescence behaviour, structure-activity relationship and molecular modelling studies
Ashraf, Jamshaid,Mughal, Ehsan Ullah,Sadiq, Amina,Bibi, Maryam,Naeem, Nafeesa,Ali, Anser,Massadaq, Anam,Fatima, Nighat,Javid, Asif,Zafar, Muhammad Naveed,Khan, Bilal Ahmad,Nazar, Muhammad Faizan,Mumtaz, Amara,Tahir, Muhammad Nawaz,Mirzaei, Masoud
, p. 7107 - 7122 (2020/08/21)
To explore new scaffolds as tyrosinase enzyme inhibitors remain an interesting goal in the drug discovery and development. In due course and our approach to synthesize bioactive compounds, a series of varyingly substituted 3-hydroxyflavone derivatives (1-23) were synthesized in one-pot reaction and screened for in?vitro against mushroom tyrosinase enzyme. The structures of newly synthesized compounds were unambiguously corroborated by usual spectroscopic techniques (FTIR, UV-Vis, 1H-, 13C-NMR) and mass spectrometry (EI-MS). The structure of compound 15 was also characterized by X-ray diffraction analysis. Furthermore, the synthesized compounds (1-23) were evaluated for their antimicrobial potential. Biological studies exhibit pretty good activity against most of the bacterial-fungal strains and their activity is comparable to those of commercially available antibiotics i.e. Cefixime and Clotrimazole. Amongst the series, the compounds 2, 4, 5, 6, 7, 10, 11, 14 and 22 exhibited excellent inhibitory activity against tyrosinase, even better than standard compound. Remarkably, the compound 2 (IC50 = 0.280 ± 0.010 μg/ml) was found almost sixfold and derivative 5 (IC50 = 0.230 ± 0.020 μg/ml) about sevenfold more active as compared to standard Kojic acid (IC50 =1.79 ± 0.6 μg/ml). Moreover, these synthetic compounds (1-23) displayed good to moderate activities against tested bacterial and fungal strains. Their emission behavior was also investigated in order to know their potential as fluorescent probes. The molecular modelling simulations were also performed to explore their binding interactions with active sites of the tyrosinase enzyme. Limited structure-activity relationship was established to design and develop new tyrosinase inhibitors by employing 2-arylchromone as a structural core in the future. Communicated by Ramaswamy H. Sarma.
