1603-46-9

Basic information

• Product Name: 3-hydroxy-2,3-dimethoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
• Synonyms: 3-Hydroxy-2,3-dimethoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
• CAS NO: 1603-46-9
• Molecular Formula: C₁₇H₁₆O₅
• Molecular Weight: 300.3059
• Mol File: 1603-46-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 465.7°C at 760 mmHg
• Flash Point: 171.4°C
• Density: 1.32g/cm³
• Vapor Pressure: 1.79E-09mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 3-hydroxy-2,3-dimethoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2,3-dimethoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one(1603-46-9)
• EPA Substance Registry System: 3-hydroxy-2,3-dimethoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one(1603-46-9)

Safety Data

• Hazardous Substances Data: 1603-46-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 577-85-5 3-hydroxyflavone 

Downstream Products

• 1808-06-6 6-methoxy-6-phenyl-6H-chromeno[3,4-b]quinoxaline 
• 80907-13-7 (E)-3-(carbethoxymethylene)-2-methoxyflavanone 
• 50526-01-7 ethyl 2?(4?oxo?2?phenyl?4H?chromen?3?yl)acetate 
• 80907-18-2 2-(4-oxo-2-phenyl-4H-chromen-3-yl)acetic acid 
• 80907-24-0 3-(bromocarbethoxymethyl)flavone 
• 80907-25-1 3-(carbethoxycyanomethyl)flavone 

Relevant articles and documents

Oxidation of Flavonols using lead(IV) acetate in acidic methanol

Oxidation of Flavonols (1a-h) and 6-propionylflavonols (1i-j) to 2,3-dimethoxy-3-hydroxyflavanones (2a-h) and 2,3-dimethoxy-3-hydroxyflavanones (2i-j), respectively using lead(IV) acetate in methanol in presence of perchloric acid and the mechanism of this transformation has been described.

HYPERVALENT IODINE OXIDATION OF FLAVONOLS USING BENZENE IN METHANOL

Hypervalent iodine oxidation of various flavonols (1a-1f) and α-naphthoflavonol (3) using benzene (HTIB) in methanol leads to the formation of 2,3-dimethoxy-3-hydroxyflavanones (2a-2f) and 2,3-dimethoxy-3-hydroxy-α-naphthoflavanone (4) respectively.HTIB resembles periodic acid in its oxidative behavior towards flavonols.

Reactions of Flav-2-enes and Flav-2-en-4-ones (Flavones)

Flav-2-enes, flavones, and 3-alkyl ethers of flavonols add alcohols and carboxylic acids in the presence of N-bromosuccinimide to give 2-alkoxy- and 2-acyloxy-3-bromoflavans which provide routes to cis-3-bromoflavans by reduction and to 3,4-diols by elimination and reaction with osmium tetraoxide.The 2-acyloxyflavans react with alcohols yielding 2-alkoxyflavans.Flavonols react with N-bromosuccinimide and alcohols to give bromine-free hemiacetals, the known 2,3-dialkoxy-3-hydroxyflavanones.