120144-45-8Relevant articles and documents
Rotationally Restricted Mimics of Rigid Molecules: Nonspirocyclic Hydantion Aldose Reductase Inhibitors
Rizzi, James P.,Schnur, Rodney C.,Hutson, Nancy J.,Kraus, Kenneth G.,Kelbaugh, Paul R.
, p. 1208 - 1213 (2007/10/02)
Sorbinil (1), a spirocyclic hydantoin, is a potent inhibitor of the enzyme aldose reductase.Simulation of the rigid spirocyclic ring orientation found in sorbinil was achieved with nonspirocyclic 5-hydantoins and 5-5'-
